Journal of Experimental Pathology

Research Article Open Access

Neuroprotective Effects of Khaya Anthotheca (Welw.) C.DC (Meliaceae) Decoction on Neurodegeneration Induced by Estrogen Depletion in Rats

Zemo Gamo Franklin, Djiogue Sefirin, Seke Etet Paul Faustin, Pieme Constant Anatole, Babiker Ali Yousif, Awounfack Charline Florence, Djikem Tadah Rudig Nikanor, Njamen Dieudonne

The cortex, hippocampus, and amygdala are among the brain regions where estrogens may act to improve cognition, memory and mood. In these regions, estrogens have many beneficial effects, including neuroprotection, neurogenesis, as well as neurotrophic, antioxidant, and anti-inflammatory effects [1-2].

Mini Review Open Access

Varying Presentations of EBV-associated Clinical Entities with Emphasis on EBV-Associated T- and NK-cell Lymphoproliferative Disorders of Childhood

Jonathan Y. Keow, Nikhil A. Sangle

The Epstein-Barr Virus (EBV) is an endemic human herpesvirus, with 90% of people demonstrating serological evidence of prior exposure to EBV. In most cases, primary infections of EBV generate mild or asymptomatic clinical courses, but may present as infectious mononucleosis if contracted during young adulthood. In a small percentage of cases, Epstein- Barr virus infection may manifest as a noncanonical reaction, yielding a wide variety of clinical manifestations.

Commentary Open Access

Identification of Laryngotracheal Stenosis During Weaning from Tracheostomy – A Clinical Conundrum

Musie T Tsehaye, Eileen Kelly, Amanda Jane Thomas

Tracheostomy insertion is a common procedure used to support weaning from mechanical ventilation or following head and neck surgery. Resolution of the clinical need for tracheostomy is followed by a process of tracheostomy weaning and subsequent decannulation.

Case Report Open Access

Adenosarcoma of Uterus with Sarcomatous Overgrowth and Rhabdomyoblastic Differentiation - A Rare Pathological Entity

Gaurav Sharma, Prachi

Uterine adenosarcoma is a rare malignancy. It is defined as a biphasic tumor composed of both sarcomatous stroma and benign epithelial components. When the sarcomatous component occupies more than 25 % of the tumor then it is referred to as the sarcomatous overgrowth which accounts to about 10% of uterine adenosarcoma cases [1].

Research Article Open Access

Antifungal Effects of PC945, a Novel Inhaled Triazole, on Candida albicans Pulmonary Infection in Immunocompromised Mice

Yuki Nishimoto, Kazuhiro Ito, Genki Kimura, Kirstie A. Lucas, Leah Daly, Pete Strong, Yasuo Kizawa

Candida spp. are often detected from fungal cultures or mycobiome analysis of respiratory secretions, but are not usually treated since, even if detected persistently, the presence is assumed to be benign colonization unless invasive candidiasis in deeply immunocompromised subjects is suspected.

Mini Review Open Access

Application of Encapsulated Probiotics in Health Care

Esmat Alemzadeh, Ahmad Oryan

Probiotics are generally defined as nonpathogenic living organisms that have beneficial effects on host health. The term “probiotic” means “for life” that is derived from Greek language. At first, probiotics was defined as substances that are produced with microorganisms and promote the other microorganisms.

Commentary Open Access

Arid5a Inroads to Immunity, Inflammation, and Cancer

Kishan Kumar Nyati, Tadamitsu Kishimoto

The immune system is essential to host defense because it senses attacking pathogens and elicits protective immune responses. Although immune responses can protect against pathogens, uncontrolled immune responses cause tissue damage and other pathological consequences through their inflammatory mediators. 

Review Article Open Access

Endoscopic Ultrasound-Guided Liver Biopsy; the Pathologist’s Perspective

Naren Nallapeta, Deepthi Rao, Ahmad H. Ali, Neal Sharma, Jamal A. Ibdah, Ghassan M. Hammoud

In this study, the safety and efficacy of liver biopsies performed by endoscopic ultrasound (EUS-LB) were compared with those performed via the traditional percutaneous route at our Medical Center between January 2018 and August 2019.