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Journal of Experimental Pathology
ISSN: 2694-5061
Repurposing of an Antifungal Drug against Gastrointestinal Stromal Tumors
Molecular docking approaches explore the receptor-ligand conformations within the binding sites of macromolecular targets [1]. Structure-based drug discovery is widely used by the scientific community in Medicinal Chemistry to estimate the ligand-receptor binding free energy by evaluating critical phenomena involved in the intermolecular recognition process [2,3].
J Exp Pathol, 2021, Volume 2, Issue 4, p151-163 | DOI: doi.org/10.33696/pathology.2.026BNT162b2 mRNA COVID-19 Vaccine Elicited Antibody Responses in COVID-19-naïve Subjects
Coronavirus disease 19 (COVID-19) mRNA vaccines have gained international acceptance and have been proven to be safe and effective [1,2]. In a study of 3,950 frontline healthcare workers with no previous laboratory documentation of COVID-19 [3],
J Exp Pathol, 2021, Volume 2, Issue 3, p117-127 | DOI: 10.33696/pathology.2.023Mechanistic and Translational Advances Using iPSC-Derived Blood Cells
The human induced pluripotent stem cell (iPSC) technology was developed more than ten years ago and has provided important tools for the mechanistic and cellular interrogation of many diseases [1]. To generate iPSC lines, somatic cells are reprogrammed into cells resembling embryonic stem cells by the overexpression of key transcription factors.
J Exp Pathol, 2020, Volume 1, Issue 2, p36-44 | DOI: 10.33696/pathology.1.010Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate
Epigenetic processes provide a mechanism for integrating metabolic inputs and translating them into various phenotypic outputs [1,2]. Indeed, epigenetic modifiers often require or are inhibited by key citric acid cycle (CAC) metabolites (e.g. succinate,
J Exp Pathol, 2020, Volume 1, Issue 2, p60-70 | DOI: 10.33696/pathology.1.009Pancytopenia: An Update
Peripheral pancytopenia is not a disease by itself; rather it describes simultaneous presence of anemia, leucopenia and thrombocytopenia resulting from a number of disease processes.
J Exp Pathol, 2020, Volume 1, Issue 1, p28-32 | DOI: 10.33696/pathology.1.005Application of Encapsulated Probiotics in Health Care
Probiotics are generally defined as nonpathogenic living organisms that have beneficial effects on host health. The term “probiotic” means “for life” that is derived from Greek language. At first, probiotics was defined as substances that are produced with microorganisms and promote the other microorganisms.
J Exp Pathol, 2020, Volume 1, Issue 1, p16-21 | DOI: 10.33696/pathology.1.003Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.