Archives of Proteomics and Bioinformatics

Research Article Open Access

First In silico Structural Model of Glucokinase-1 from Phytophthora infestans Reveals a Possible Pyrophosphate Binding Site

Liara Villalobos-Piña, Ascanio Rojas, Héctor Acosta

Phytophthora infestans is the causal agent of late blight disease, which affects potato and tomato crops worldwide, that brings about significant economic losses in the production of these crops. The PITG_06016 gene codes for one of the 7 glucokinases present in this phytopathogen.

Research Article Open Access

Do Support Vector Machines Play a Role in Stratifying Patient Population Based on Cancer Biomarkers

Ben Lanza, Deepak Parashar

Cancer is a worldwide public health issue that affects millions of people every year. In 2018 there were 17 million newly documented cases of cancer globally (8.8 million in men and 8.2 million in women), leading to 9.6 million deaths. Cancer is a vastly heterogeneous disease, with over 100 different types of cancer currently identified in humans; the most common types of cancer are lung, female breast, bowel and prostate, these four types account for more than 40% of all new cancer case

Commentary Open Access

Possible Functions of the Conserved Peptides Encoded by the RNA - precursors of miRNAs in Plants

Sergey Y. Morozov, Dmitriy Y. Ryazantsev, Tatiana N. Erokhina

MicroRNAs (miRNAs) are short double-stranded regulatory molecules derived from precursor transcripts called primary miRNAs (pri-miRNAs) and transcribing in the nucleus from chromosomal DNA by the RNA polymerase II. These pri-miRNAs were shown to contain internal imperfect hairpin structures which are processed by DCL (dicer-like) enzyme

Research Article Open Access

Ramifications of the Diverse mRNA Patterns in Acanthamoeba royreba

Richard Tyndall, Ibne Ali, Anthony Newsome

Acanthamoeba was first described by Castellani and represents single-cell eukaryotes existing as either cellular trophozoites (25–40 ?m) or under adverse conditions (desiccation, lack of food, and extreme pH or temperature fluctuations), as dormant cysts (13–20 ?m). The cysts are known to be resistant to antibiotics, the effects of chlorine, and very low temperatures, and have been shown to maintain viability for over 20 years.

Research Article Open Access

RANDOMIZE: A Web Server for Data Randomization

Agaz H. Wani, Don Armstrong, Jan Dahrendorff, Monica Uddin

Deoxyribonucleic acid (DNA) methylation is a critical type of epigenetic modification that typically occurs in a specialized region of DNA, CpG-rich regions in the mammalian genome and is associated with regulating gene expression. Previous studies have revealed a strong association of change in DNA methylation with various diseases such as cancer, obesity and posttraumatic stress disorder (PTSD).

Commentary Open Access

A Bioinformatics Protocol for Rational Design of Peptide Vaccines and the COVID-19 Rampage

Ashesh Nandy, Subhas C Basak, Smarajit Manna

The currently ongoing coronavirus pandemic, the SARSCOV- 2, interchangeably referred to as the COVID-19 infection, has in a short span of time altered the ways and means of almost all of mankind. So strong has been its effect that all human activity ceased in one way or another for a considerable time, led to significant loss of life and economic drain of.