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Archives of Obstetrics and Gynaecology

ISSN: 2692-787X

2021

Volume 2, Issue 1, p1-23

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Case Series Open Access

Intrauterine Device Embedment Resulting in Its Fracture: A Case Series

Carlos M. Fernandez, Elliot M. Levine, Marie Cabiya, Imaan Ansari, Leah Delfinado

As gynecologic providers continue to provide intrauterine devices (IUDs) for long-acting reversable contraception (LARC) with insertion of those devices, the associated complication rate needs to be well-understood, so that patients can make properly informed shared healthcare decisions.

Arch Obstet Gynecol, 2021, Volume 2, Issue 1, p1-4 | DOI: 10.33696/Gynaecology.2.009
Commentary Open Access

Recommendation of Tetanus Toxoid Vaccination for Pregnant Females in a Country that Achieved Elimination of Maternal and Neonatal Tetanus. A commentary on the Study: Knowledge and Health Beliefs of Reproductive-age Women in Alexandria about Tetanus Toxoid Immunization

Azza A. Mehanna

The study “knowledge and health beliefs of reproductive-age women in Alexandria about tetanus toxoid immunization” has shed a new light on the attitude of obstetricians in Alexandria (Egypt) towards recommending tetanus toxoid vaccination to pregnant females.

Arch Obstet Gynecol, 2021, Volume 2, Issue 1, p5-8 | DOI: 10.33696/Gynaecology.2.010
Review Article Open Access

Evaluation and Management of chronic Hypertension in Pregnancy

Sangeeta Yadav, Neeta Singh, Mandakini Pradhan

Chronic hypertension is present in 1-2% of pregnant women. Women with chronic hypertension are at an increased risk of maternal and perinatal complications when compared with normotensive women.

Arch Obstet Gynecol, 2021, Volume 2, Issue 1, p9-15 | DOI: 10.33696/Gynaecology.2.011
Short Communication Open Access

Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery in Stage 1B2 Cervical Cancer

JWM Aarts, PLM Zusterzeel

In 2020 we published a series of 18 patients who underwent neoadjuvant chemotherapy (NACT) and vaginal radical trachelectomy (VRT) as a fertility sparing alternative in stage 1B2 cervical cancer.

Arch Obstet Gynecol, 2021, Volume 2, Issue 1, p16-19 | DOI: 10.33696/Gynaecology.2.012
Commentary Open Access

Gene Therapy for Sickle Cell Disease: Start of a New Era

Norman Ginsberg, Lee P Schulman

This manuscript reviews treatment of Sickle Cell disease over time. The application of allogeneic stem cells proved the sickle cell disease could be permanently corrected and cured but limited to those with a compatible donor.

Arch Obstet Gynecol, 2021, Volume 2, Issue 1, p20-23 | DOI: 10.33696/Gynaecology.2.013
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Recommended Articles

Cardiac Stem Cell Therapy, Quo Vadis

Cardiovascular disease causes 30% of global mortality and is still the number one cause of death worldwide. A main patho-physiological process is the coronary disease leading to malperfusion and ischemic cardiac disease as well as cardiac infarction.

Evaluation and Management of chronic Hypertension in Pregnancy

Chronic hypertension is present in 1-2% of pregnant women. Women with chronic hypertension are at an increased risk of maternal and perinatal complications when compared with normotensive women.

Gene Therapy for Sickle Cell Disease: Start of a New Era

This manuscript reviews treatment of Sickle Cell disease over time. The application of allogeneic stem cells proved the sickle cell disease could be permanently corrected and cured but limited to those with a compatible donor.

Needed, Assays for “Fetal Hemoglobin levels” in RBCs: Fetomaternal Hemorrhage and Expanded Applications in Sickle Cell Disease Management Could Forge an Evolution in Cellular Diagnostics

Treatment of sickle cell disease (SCD) remains varied with only a minority of patients benefiting from stem cell transplant as a near cure. Others await the promise of more effective and less toxic treatments than hydroxyurea, especially children who are most susceptible to the morbidities and mortalities of SCD. The recent report of Hebert, Rakotoson et al. points to an evolution of in vitro diagnostics (IVD) testing of blood cells with the emerging need for cell-by-cell measurement of red blood cell (RBC) specific hemoglobin variant levels. The study further provides clinical validation as to the utility of measuring HbF content in RBCs of SCD patients, not just as a prognostic test, but likely serving as a companion diagnostic in phase 3 clinical trials of new SCD therapies. 

Preventing Stroke in Sickle Cell Disease: 2021. The Role of Transcranial Doppler Ultrasound (TCD) When the Use of Transfusion is Problematic

While TCD is an indicator of risk, not a biopsy diagnosis (such as proof of cancer), at some point in the velocity spectrum the high velocity detected by TCD reaches what many believe is an unacceptable risk of stroke.

Phlebotomy in Congenital Erythrocytosis and in Sickle Cell Disease HbSC

The inherited haemoglobin disorders, including thalassemias and haemoglobinopathies, are the most common genetic diseases and the clinical laboratory is essential in the diagnosis. Haemoglobinopathies are monogenic disorders in the genes that encode globin chains that can lead to a defective globin production or a variant in the haemoglobin structure.

A Rare Blood Malignancy in a Genetic Hematological Disorder: Polycythemia Vera (PV) in Sickle Cell Disease (SCD)

To delineate the etiology, symptomatology, and treatment of Polycythemia Vera in adults with Sickle Cell Disease. The current review contains a review of the 4 case reports that we found on the topic. To our knowledge, no other case reports exist.

Voting Engagement among Adults with Sickle Cell Disease (SCD): Health Matters

The Voting Rights Act of 1965 was established to enforce voting rights guaranteed by the Fourteenth and Fifteenth amendments. Unfortunately, Blacks faced additional barriers when attempting to exercise their right to vote. Moreover, focusing on voting specifically among adults living with Sickle Cell Disease (SCD), we assessed voter participation as a form of advocacy to evaluate if political involvement was related to psychological status. 

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