The Hippo pathway has well-established roles in physiology and pathology. However, functions for the Hippo pathway in modulating interactions with the immune system have only recently been elucidated. In this review, we provide a brief update on our previous summary of the field. More specifically, we highlight literature that demonstrates a role for the Hippo pathway in modulating the antitumour immune response, primarily through acting on PD-L1. We continue to discuss Hippo pathway involvement in modulating inflammation, both sterile and in the context of pathogenic infection. We further review emerging evidence implicating Hippo pathway proteins in immune-related processes across species. Finally, we provide an update into the vital immune cell-intrinsic roles of the Hippo pathway core components and draw attention to opportunities for future study.
Hippo pathway, Cancer, Immunology, Immunotherapy, Inflammation, MST1/2, LATS1/2, YAP, TAZ, PD-L1