Review Article Open Access
Volume 2 | Issue 6 | DOI: https://doi.org/10.33696/immunology.2.054

The Hippo Pathway, Immunity, and Cancer: An update

  • 1Department of Medicine, University of Toronto, Toronto, Ontario, M5S 3H2, Canada
  • 2The Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8L6, Canada
  • #Both authors contributed equally to this work
+ Affiliations - Affiliations

Corresponding Author

Helena J. Janse van Rensburg, ellen.jansevanrensburg@mail.utoronto.ca

Received Date: July 15, 2020

Accepted Date: August 26, 2020


The Hippo pathway has well-established roles in physiology and pathology. However, functions for the Hippo pathway in modulating interactions with the immune system have only recently been elucidated. In this review, we provide a brief update on our previous summary of the field. More specifically, we highlight literature that demonstrates a role for the Hippo pathway in modulating the antitumour immune response, primarily through acting on PD-L1. We continue to discuss Hippo pathway involvement in modulating inflammation, both sterile and in the context of pathogenic infection. We further review emerging evidence implicating Hippo pathway proteins in immune-related processes across species. Finally, we provide an update into the vital immune cell-intrinsic roles of the Hippo pathway core components and draw attention to opportunities for future study.


Hippo pathway, Cancer, Immunology, Immunotherapy, Inflammation, MST1/2, LATS1/2, YAP, TAZ, PD-L1

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