Background: Preterm premature rupture of membrane (PPROM) is the rupture of fetal membrane before 37 weeks of gestation.
Objectives: The aim of the current study was to assess the effects of vaginal probiotic administration on perinatal outcomes in patients with PPROM.
Methods: Sixty pregnant women with PPROM were randomly divided into two groups (n=30). In the first group, in the first 48 hours of hospitalization, 2 gr of intravenous ampicillin and 500-mg amoxicillin capsules were administered for five days. In the second group, the patients received one vaginal probiotic supplement for ten days in addition to receiving an antibiotic treatment similar to the first group. Finally, the perinatal outcomes were examined.
Results: NICU hospitalization was significantly lower in the second group than in the first group (P<0.05). The Apgar scores 1 and 5 minutes after birth and the newborns’ weight at birth were higher in the second group than in the first group (P<0.05). Pregnancy duration was longer in the second group than in the first group (P<0.05).
Conclusion: The results of this study showed that the administration of vaginal probiotics in PPROM patients may be effective in delaying childbirth and reducing neonatal complications.
Probiotic, Vaginal, Preterm premature rupture of membrane