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Research Article Open Access
Volume 3 | Issue 2 | DOI: https://doi.org/10.33696/Gynaecology.3.030

The Effects of Vaginal Probiotic Administration on Perinatal Outcomes in Patients with Premature Preterm Rupture of Membrane

  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • 2Department of Physiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  • 3Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
+ Affiliations - Affiliations

Corresponding Author

Nasrin Soufizadeh, Nsoofizadeh@hotmail.com

Received Date: May 12, 2022

Accepted Date: August 11, 2022

Abstract

Background: Preterm premature rupture of membrane (PPROM) is the rupture of fetal membrane before 37 weeks of gestation.

Objectives: The aim of the current study was to assess the effects of vaginal probiotic administration on perinatal outcomes in patients with PPROM.

Methods: Sixty pregnant women with PPROM were randomly divided into two groups (n=30). In the first group, in the first 48 hours of hospitalization, 2 gr of intravenous ampicillin and 500-mg amoxicillin capsules were administered for five days. In the second group, the patients received one vaginal probiotic supplement for ten days in addition to receiving an antibiotic treatment similar to the first group. Finally, the perinatal outcomes were examined.

Results: NICU hospitalization was significantly lower in the second group than in the first group (P<0.05). The Apgar scores 1 and 5 minutes after birth and the newborns’ weight at birth were higher in the second group than in the first group (P<0.05). Pregnancy duration was longer in the second group than in the first group (P<0.05).

Conclusion: The results of this study showed that the administration of vaginal probiotics in PPROM patients may be effective in delaying childbirth and reducing neonatal complications.

Keywords

Probiotic, Vaginal, Preterm premature rupture of membrane

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