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Journal of Physical Medicine and Rehabilitation

ISSN: 2690-0297

Review Article Open Access
Volume 5 | Issue 1 | DOI: https://doi.org/10.33696/rehabilitation.5.035

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder

Navid Fazlinejad1, Samaneh Hosseini2, Shirin Yaghoobpoor3, Mina Dehghani4, Hanieh Bazrafshan5, Shokoufeh Khanzadeh6, Brandon Lucke-Wold7,*
  • 1Khodadoust Eye Hospital, Shiraz, Iran
  • 2Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • 3Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 4School of medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • 5Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • 6Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  • 7Endovascular Fellow, University of Florida, Department of Neurosurgery, Gainesville, FL, USA
+ Affiliations - Affiliations

Corresponding Author

Brandon Lucke-Wold, Brandon.Lucke-Wold@neurosurgery.ufl.edu

Received Date: April 11, 2023

Accepted Date: July 14, 2023

Citation:

Fazlinejad N, Hosseini S, Yaghoobpoor S, Dehghani M, Bazrafshan H, Khanzadeh S, et al. The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder. J Phys Med Rehabil. 2023;5(1):16-25.


Copyright: © 2023 Fazlinejad N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO.

Methods: Ten studies were selected that were sufficiently high quality and then checked for quality. The studies were organized by English language and selective inclusion criteria.

Results: NLR was significantly increased in NMO patients compared to controls. The ratio was specifically proportional to severity of disease. More severe disease had a higher ratio.

Conclusion: NLR offers a reliable and affordable method for early detection of disease severity. This can help guide appropriate treatment selection and monitor treatment response.

Keywords

Neuromyelitis optica spectrum disorder, Neutrophil to lymphocyte ratio, Systematic review

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