Commentary Open Access
Volume 1 | Issue 2 | DOI: https://doi.org/10.33696/Neurol.1.007

Skeletal Muscle Weakness Often Occurs in Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)

  • 1C2VN UMR Inra Inserm, Faculty of Medicine, Aix-Marseille University, France
  • 2Department of Internal Medicine, European Hospital, Marseille, France
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Corresponding Author

Frédérique Retornaz, f.retornaz@hopital-europeen.fr

Received Date: April 16, 2020

Accepted Date: May 14, 2020


This commentary complements data reported in Clinical Biomechanics [1] reporting reduced maximal handgrip strength in numerous patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) in proportion to their lowered maximal physical performances. The causes of muscle weakness in these patients are open to discussion. Literature data reveal a reduction of central command to skeletal muscles in some ME/CFS patients, related to encephalomyelitis. Altered muscle membrane excitability, that is “peripheral fatigue”, is also described in relation with an imbalance of the oxidant / anti-oxidant status. On the other hand, subgroups of chronically fatigued patients with clinical criteria of ME/CFS do not suffer from any muscle weakness. Thus, clinical data do not sufficiently clarify homogeneous ME/CFS pathology.

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