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Journal of Clinical Cardiology

ISSN: 2694-5088

Research Article Open Access
Volume 4 | Issue 2 | DOI: https://doi.org/10.33696/cardiology.4.044

Short-Term Outcomes Following Transcatheter Aortic Valve Implantation: Classical Low-Flow Low-Gradient Versus Normal-Flow Low-Gradient Severe Aortic Stenosis

Benjamin Fogelson1,*, Raj Baljepally1, Hassan Tahir1, James Livesay1, Tyler Coombes1, Chirag Patel1, Ghassan Wadi1, Raymond Dieter III2
  • 1Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
  • 2Department of Cardiothoracic Surgery, University of Tennessee Medical Center, Knoxville, TN 37920, USA
+ Affiliations - Affiliations

Corresponding Author

Benjamin Fogelson, bafogelson@utmck.edu

Received Date: September 29, 2023

Accepted Date: October 11, 2023

Citation:

Fogelson B, Baljepally R, Tahir H, Livesay J, Coombes T, Patel C, et al. Short-Term Outcomes Following Transcatheter Aortic Valve Implantation: Classical Low-Flow Low-Gradient Versus Normal-Flow Low-Gradient Severe Aortic Stenosis. J Clin Cardiol. 2023;4(2):44-51.


Copyright: © 2023 Fogelson B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Both classical severe low-flow low-gradient aortic stenosis (LFLG-AS) and severe normal-flow low-gradient aortic stenosis (NFLG-AS) patients undergo transcatheter aortic valve implantation (TAVI). However, few studies have compared outcomes between the two groups. Our study aimed to assess short term post-TAVI outcomes between classical LFLG-AS and NFLG-AS.

Methods: We conducted a retrospective, single-center, analysis of 206 patients who underwent TAVI between January 2011 to September 2020. Of these, 44 (males: 33) had classical LFLG-AS and 162 (males: 89) had NFLG-AS. Six-month primary outcomes included all-cause and cardiovascular mortality. Multiple secondary outcomes were assessed including stroke, myocardial infarction (MI), new-onset atrial fibrillation, acute kidney injury (AKI), major bleeding, vascular complications, and repeat hospitalizations from cardiac causes.

Results: The cumulative six-month all-cause and cardiovascular mortality were similar between classical severe LFLG-AS and NFLG-AS patients (6.81 % vs. 4.32 %, P = 0.49 and 2.27 % vs. 2.47 %, P = 0.93 respectively). All secondary outcomes were also similar, except for a statistically significant higher rate of AKI in patients with classical LFLG-AS (P = < 0.0001).

Conclusion: Except for a higher incidence of AKI in patients with severe classical LFLG-AS, six-month post-TAVI outcomes did not differ between classical LFLG-AS and NFLG-AS.

Keywords

TAVI, Aortic stenosis, Low flow low gradient severe aortic stenosis, Normal flow low gradient severe aortic stenosis

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