Commentary Open Access
Volume 3 | Issue 3 | DOI: https://doi.org/10.33696/cancerimmunol.3.050
Profiling the Energy Metabolism at the Cell Subpopulation Level
Karim Benihoud1, Catherine Brenner1,*
- 1Université Paris-Saclay, CNRS, Institut Gustave Roussy, Aspects métaboliques et systémiques de l’oncogénèse pour de nouvelles approches thérapeutiques, 94805, Villejuif, France
Corresponding Author
Dr. Catherine Brenner, catherine.brenner@universite-paris-saclay.fr
Received Date: May 26, 2021
Accepted Date: July 14, 2021
Benihoud K, Brenner C. Profiling the Energy Metabolism at the Cell Subpopulation Level. J Cancer Immunol. 2021; 3(3): 147-150.
Copyright: © 2021 Benihoud K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords
Cancer, Metabolism, Mitochondria, Oxidative stress, Omics
Recommended Articles
Manipulating Oxidative Stress Following Ionizing Radiation
It is now well accepted that the ionizing radiation-generated reactive oxygen species (ROS), that constitute ~2/3 of the effects of external beam radiation, do not only produce direct tumor cell death, but also affect the surrounding microenvironment. Moreover, this indirect effect of radiation may result in systemic effects, specifically the initiation of an inflammatory response.
Reduced BCR Signaling and a Metabolic Shift Accompanies Malignant Progression of Follicular Lymphoma: A Lesson from Transcriptomics
In the manuscript entitled “The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma”, we reported recent advances in our understanding of how the gene expression profile of ion channels and transporters (ICT-GEP) contributes to identify specific signatures associated with Follicular Lymphoma (FL), with those FL that acquire chemoresistance after a relapsing-remitting course, and with the more aggressive Diffuse Large Cell Lymphoma (DLBCL), which in some cases represent the evolution of FLs.
Using Mitochondrial Trifunctional Protein Deficiency to Understand Maternal Health
Fatty acid oxidation disorders unfortunately can result in the sudden unexplained death of infants. Mitochondrial trifunctional protein (MTP) deficiency is one such disease where long-chain fatty acids cannot be fully oxidized through beta-oxidation which, can lead to cardiac arrythmias in an infant.
A New Window onto the Pacemaker of the Heart, the Sinus Node, Provided by Quantitative Proteomics and Single- Nucleus Transcriptomics
Hypothesis-driven research has dominated biomedical science for at least the past century. There are many papers and grant applications that will have been rejected because they are not hypothesis-driven. For example, Haufe reports that the NIH guidelines for RO1 grants states that “A strong grant application is driven by a strong, solid hypothesis with clear research objectives”.
Mitochondria Autoimmunity and MNRR1 in Breast Carcinogenesis: A Review
We review here the evidence for participation of mitochondrial autoimmunity in BC inception and progression and propose a new paradigm that may challenge the prevailing thinking in oncogenesis by suggesting that mitochondrial autoimmunity is a major contributor to breast carcinogenesis and probably to the inception and progression of other solid tumors. It has been shown that MNRR1 mediated mitochondrial-nuclear function promotes BC cell growth and migration and the development of metastasis and constitutes a proof of concept supporting the participation of mitochondrial autoimmunity in breast carcinogenesis.