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Review Article Open Access
Volume 6 | Issue 5 | DOI: https://doi.org/10.33696/immunology.6.206

Polyamines: Key Players in Immunometabolism and Immune Regulation

  • 1Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA
  • 2Department of Pathology, Case Western Reserve University, Cleveland, Ohio, 44106, USA
  • 3Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio, 44106, USA
  • 4Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA
+ Affiliations - Affiliations

Corresponding Author

Pushpa Pandiyan, pxp226@case.edu

Received Date: August 31, 2024

Accepted Date: October 10, 2024

Abstract

Polyamines are small organic molecules ubiquitously present in all living organisms and function as crucial regulators of biological processes ranging from fundamental cellular metabolism to immune regulation. Dysregulation of polyamine metabolism has been implicated in numerous diseases, including neurodegenerative disorders, inflammatory conditions, autoimmune diseases, and cancer. This review provides an overview of pathophysiology of these conditions, highlighting polyamines’ role in immunometabolic alterations in the context of immune regulation. Exploring the intricate mechanisms of polyamine metabolism holds promise for advancing our understanding of disease processes and developing potential innovative therapeutic interventions.

Keywords

Polyamines, HIV, Immune regulation, Immunometabolism, Tumorigenesis, Cancer

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