The transition of surgical procedures from hospital-based to office-based settings has raised important considerations regarding patient safety, cost-effectiveness, and procedural outcomes. The recent study by Cremers et al. (2025) evaluates the safety and efficacy of office-based pterygium surgery, reporting low complication rates, minimal postoperative pain, and significant cost savings. Of particular neurological interest is the reported case of central retinal artery occlusion following a peribulbar injection containing epinephrine, highlighting the potential vascular risks associated with local anesthetic administration. This commentary explores the broader implications of these findings for neurological practice, emphasizing the importance of vascular risk mitigation, interdisciplinary collaboration, and the expanding role of office-based procedures in modern medicine. Understanding the safety protocols employed in ophthalmology can inform best practices in neurology, particularly regarding outpatient procedural safety and the management of patients with complex comorbidities.

Cerebrovascular regulation, Clinical Neruology, Neuro-immunology