Commentary Open Access
Volume 4 | Issue 2 | DOI: https://doi.org/10.33696/Nanotechnol.4.044

Immobilized Cell Bioreactor Industrialization in the Development of an Innovative Optical Biosensor Technology

  • 1Food Biotechnology Group, Department of Chemistry, University of Patras, 26500 Patras, Greece
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Corresponding Author

Athanasios A. Koutinas, A.A.Koutinas@upatras.gr

Received Date: June 04, 2023

Accepted Date: August 11, 2023


This commentary shows the development of a new optical biosensor, based on cell immobilization of Pseudomonas Fluorescens HK44, in nano and micro-tubular cellulose (TC) and a mixture of carbohydrate nanotubes (CHNTs) and carbohydrate micro-tubes (CHMTs). Methodology follows, this biocatalyst can be industrialized with the use of a single tank immobilized cell bioreactor (ICB). A techno-economic analysis was conducted within the framework of it by designing a process flow sheet with mass and energy balance. According to its case study, the investment is 227,800 euros, and the daily production cost is 1434 euros, with a maximum daily added value of 25,000 euros. The discussion revealed that novel research proposals and a novel study concept are being developed in the field of biosensors. The results are supported by papers published on ICB area development. The problem that leads to this commentary is industrialization of ICB, in the case of a simple biosensor development using immobilized cells and it is the objective.


Bioreactor, Biosensor, Cell, Immobilization, Optical

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