Review Article Open Access
Volume 2 | Issue 1 | DOI: https://doi.org/10.33696/Nanotechnol.2.019

Functionalized Folic Acid with Chitosan and PAMAM Dendrimers for Delivery of DNA and RNA

  • 1Department of Chemistry-Biochemistry-Physics, University of Québec in Trois-Rivières, C. P. 500, TR (Québec) Canada
  • 2Department of Medicine, Rutgers Robert Wood Johnson Medical School, KTL N102, 675 Hoes Lane, Piscataway, NJ 08854, USA
  • 3Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
+ Affiliations - Affiliations

Corresponding Author

H. A. Tajmir-Riah, heidar-ali.tajmir-riahi@uqtr.ca

Received Date: April 19, 2021

Accepted Date: May 14, 2021


In this review, we explore the potential applications of functionalized folic acid-polymer nanoparticles in nucleic acids delivery. Folic acid-chitosan (carbohydrates) and folic acid-PAMAM (dendrimers) of different polymer sizes were used to conjugate with DNA and tRNA in vitro. Thermodynamic analysis showed that conjugation of DNA and tRNA to nanoparticles occurred via hydrophilic, hydrophobic, H-bonding and van der Waals contacts. Major alterations of DNA and RNA morphology occurred by nanocarrier interaction. These results indicate that functionalized folic acid-nanoparticles can deliver DNA and RNA to target sites.


DNA, tRNA, Gene delivery, Folic acid-polymer, Thermodynamics, Transmission electron microscopy

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