Commentary Open Access
Volume 4 | Issue 1 | DOI: https://doi.org/10.33696/rehabilitation.4.024

Exercise Benefits on Alzheimer’s Disease

  • 1Department of Pharmacology, Laboratory of Aging and Nervous Diseases (SZS0703), Jiangsu Key Laboratory of Neuropsychiatric Disease, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
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Corresponding Author

Fang Lin, linfang-1@suda.edu.cn

Received Date: November 02, 2021

Accepted Date: December 09, 2021


Alzheimer’s disease (AD) is a major threat to the health of the elderly, and there are few drugs that can completely cure AD. Here we find that longterm exercise improves cognitive impairment and motor coordination in AD mice, maintains lysosomal Golgi morphology, promotes lysosomal maturation to enhance lysosomal function, stimulates enhanced effects of TFEB and AMPK mediated acetyl-CoA synthetase2 (ACSS2) for lysosomal biogenesis thereby increasing amyloid degradation and reducing its accumulation in the hippocampus and cortex.



Exercise, Lysosome function, Alzheimer’s disease

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