Life sciences involve a broad overview of fundamental research of high interest, accompanied by the development of applications based on emerging needs. The generation of non-classical light is a high-impact area of research that could lay the foundation for functional materials, particularly in applications requiring tracking and switchable (on/off) properties. In this regard, the present communication is intended to present and discuss how natural and synthetic bio-structures, along with Nanotechnology, could provide versatile platforms for developing functional and multi-functional structures accompanied by the generation of novel non-classical light pathways. The design involves multidisciplinary research, where the chemistry of nano- and microscale surfaces can be leveraged to tune interactions and enable further functionalization. Moreover, bioconjugation and genetic engineering can be employed to modify material composition and properties. In this context, the biostructure is not merely the target—it becomes an integral part of the functional biomaterial designed to deliver specific, targeted properties. Thus, the design of nano-biostructures requires interdisciplinary knowledge from different research fields such as nanomaterials, nanotechnology, biomaterials, biochemistry, and biotechnology. The targeted functions span a broad range, as highlighted in this short communication, which offers insights and analysis to stimulate discussion on leveraging fundamental knowledge in photonics and biophotonics. New phenomena related to light and electronic interactions—ranging from the nanoscale to the quantum level—are explored through nano–bio interactions, creating new modes of energies, non-classical light generation, and enhanced physical effects.

Enhanced nanomaterials and nanotechnology, particularly in the context biological media with different interests are highlighted. Consequently, life sciences and biomedical developments are central to advancing both fundamental knowledge and practical innovations in areas such as biophotonics, biotechnology, and related fields.

Nanotechnology, Biotechnology, Nano-biostructures, Micro-machines, Hybrid nano-biostructures, Functional nano-biostructures, Nano-bio-platforms