Commentary Open Access
Volume 7 | Issue 3 | DOI: https://doi.org/10.33696/cancerimmunol.7.111
Blood Clotting Contributes to a Malignant Glioma Phenotype: A Commentary
Lynn M. Knowles1, Tamara C. Kiwitt2, Jan Pilch2,*
- 1Institute of Clinical Hemostaseology and Transfusion Medicine, Saarland University and University Medical Center, Homburg/Saar, Germany
- 2Institute for Transfusion Medicine and Hemostasis, University Hospital Augsburg, Augsburg, Germany
Corresponding Author
Jan Pilch, jan.pilch@uk-augsburg.de
Received Date: June 03, 2025
Accepted Date: August 12, 2025
Knowles LM, Kiwitt TC, Pilch J. Blood Clotting Contributes to a Malignant Glioma Phenotype: A Commentary. J Cancer Immunol. 2025;7(3):123–127.
Copyright: © 2025 Knowles LM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
Reduced BCR Signaling and a Metabolic Shift Accompanies Malignant Progression of Follicular Lymphoma: A Lesson from Transcriptomics
In the manuscript entitled “The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma”, we reported recent advances in our understanding of how the gene expression profile of ion channels and transporters (ICT-GEP) contributes to identify specific signatures associated with Follicular Lymphoma (FL), with those FL that acquire chemoresistance after a relapsing-remitting course, and with the more aggressive Diffuse Large Cell Lymphoma (DLBCL), which in some cases represent the evolution of FLs.
Acute Abdomen due to Perforation of Small Bowel Malignant Melanoma Metastasis
Metastatic malignant melanoma of the small bowel is a rare and aggressive disease, without specific symptoms. Due to that, most cases are diagnosed in advanced stages, presenting as an acute abdomen in situations of bowel obstruct ion or perforation. We present the case of a 56-year-old male who was admitted for generalized edema and developed an acute abdomen secondary to perforation of small bowel malignant melanoma metastasis, with lymph node invasion.
Dual Expression of GARP in Immune and Glioma Cells: Yet Another Mechanism of Cancer Immune Escape
Glioblastomas (GB) are amongst the most lethal human tumors exhibiting a highly aggressive behavior manifested by tumor cell infiltration into surrounding tissue. Furthermore, GBs are notorious for their high degree of resistance to cytotoxic treatments [1-3].
Susceptibility of Malignant Brain Tumors to 5-aminolaevulinic Acid Mediated Photodynamic Therapy: Direct Phototoxicity and Immunological Effects
Recently we published the article ‘Accumulation of protoporphyrin IX in medulloblastoma cell lines and sensitivity to subsequent photodynamic treatment’. In this commentary, we review protoporphyrin IX accumulation after application of 5-aminolaevulinic acid and the resulting sensitivity of medulloblastoma cells to photodynamic therapy. We compare the results to glioblastoma cells, including glioblastoma stem-like cells, and address the contribution of the transporter adenosine triphosphate binding cassette subfamily G member 2 (ABCG2) as well as the enzyme ferrochelatase to the process.
Current Advances in CAR T Cell Therapy for Malignant Mesothelioma
Malignant mesothelioma is a relatively rare malignancy arising in the body’s serosal surfaces, with malignant pleural mesothelioma (MPM) being the most common type. It is characterized by local spread within the thorax, poor prognosis and resistance to treatment. The development of various immunotherapeutic options has provided a new way- and hope- in treating cancer patients. Chimeric antigen receptor (CAR) T cell therapy has been proven very successful in treating hematological cancers, like leukemias and lymphomas, and its use is now being tested in solid tumors.