Review Article Open Access
Volume 2 | Issue 1 | DOI: https://doi.org/10.33696/Gastroenterology.2.025

Advances in Functionalized Hybrid Biopolymer Augmented Lipid-based Systems: A Spotlight on Their Role in Design of Gastro Retentive Delivery Systems

  • 1Thermo Fisher Scientific, Cincinnati, OH 45237, USA
  • 2Department of Bioanalytical Chemistry, Covance Laboratories, Madison, WI 53704, USA
  • 3Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA
+ Affiliations - Affiliations

Corresponding Author

Mallesh Kurakula, mkrakula@memphis.edu

Received Date: February 05, 2021

Accepted Date: February 22, 2021


Biopolymers are the polymers extracted from living organisms either from renewable plant or animal sources are gaining importance due to their better biodegradability, biocompatibility, less/no immunogenicity, less/no toxicity, and availability. Polysaccharides (e.g., chitosan, cellulose), polypeptides (e.g., collagen, silk), and polynucleotides are the important class of biopolymers that are finding multidisciplinary applications in biomedical fields. At the other end, lipid-based systems are having their special concern in drug delivery due to their advantages over other excipient systems. In this present review, various classes of biopolymers and their fusion with conventional lipids for amalgam entity using advanced techniques for futuristic biomedicine applications are outlined. The comprehensive focuses on upbringing the importance and types of functionalization techniques explored for designing deliverable for various unmet clinical needs. Along with recent trends, the scrutiny even addresses the future perspective of these hybrid systems impacting in addressing the pharceutical, formulational and clinical challenges in treating gasteroentric diseases.


Lipid, Biopolymers, Functionalization, Drug delivery, Gastro retentive systems

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