Short Communication Open Access
Volume 1 | Issue 1 | DOI: https://doi.org/10.33696/pathology.1.004
A New Player in an Old Story: FBXO16 Prevents Breast Cancer Tumorigenesis through Disrupting Cellular Function of Nuclear β-Catenin
Debasish Paul1,2, Srikanth Rapole1, Manas Kumar Santra1,*
- 1National Centre for Cell Science, S. P. Pune University Campus, Ganeshkhind Road, Pune, Maharashtra, India 411007
- 2Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Corresponding Author
Manas Kumar Santra, manas@nccs.res.in
Received Date: August 13, 2020
Accepted Date: September 02, 2020
Paul D, Rapole S, Santra MK. A New Player in an Old Story: FBXO16 Prevents Breast Cancer Tumorigenesis through Disrupting Cellular Function of Nuclear β-Catenin. J Exp Pathol 2020; 1(1): 22-27.
Copyright: © 2020 Paul D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Aberrant nuclear accumulation of β-catenin is associated with cancer pathogenesis; however, the regulation of nuclear β-catenin was largely remained elusive. In J. Pathology, Paul et al. elucidated the molecular mechanism of accumulation of nuclear β-catenin in cancer [1].
Recommended Articles
The Nature of Radiation-induced Inherited Recessive Gene Mutations in Drosophila Melanogaster
The nature of gene mutations induced by ionizing radiation in germ cells and transmitted to offspring remains one of the most important problems in radiation genetics of higher eukaryotes. The data accumulated in this field were obtained by different authors under different experimental conditions which does not give a complete insight about the nature of radiation-induced inherited mutations at different genome levels (chromosome, gene, DNA).
Commentary on NOBOX Mutations in Premature Ovarian Insufficiency
NOBOX is an ovarian specific transcription factor that plays an important role in follicular growth and survival. Nineteen NOBOX variants have been previously associated with premature ovarian insufficiency (POI). Disease severity in patients with heterozygous and homozygous mutations largely overlap however, hampering genotype-phenotype correlations. We recently reported the first case of biallelic truncating mutations (NM_001080413.3 (NOBOX):c.826C>T, p.(Arg276*) and NM_001080413.3(NOBOX):c.1421del, p.(Gly474Alafs*76)) of NOBOX in two Belgian sisters with POI.
Involvement of D-Loop Mutations in the Occurrence of Ovarian Carcinoma
Each cell in the body contains hundreds of mitochondria; each mitochondrion contains several DNA molecules, each carrying 37 genes that participate in the production of energy.
A New Player in an Old Story: FBXO16 Prevents Breast Cancer Tumorigenesis through Disrupting Cellular Function of Nuclear β-Catenin
β-Catenin is the central modulator of the canonical Wnt signaling pathway. Upon Wnt on state, β-Catenin is translocated to the nucleus and function as a transcription coactivator for several oncogenes. In Wnt off state, β-catenin is mostly localized in the cytoplasm and sequestered by the destruction complex, the negative regulator of β-catenin expression [2,3].
Plasminogen Activator Inhibitor-1 and Oncogenesis in the Liver Disease
Hepatocellular carcinoma (HCC) is a significant cause of cancer mortality worldwide. Chronic hepatic inflammation and fibrosis play a critical role in the development of HCC. Liver fibrosis develops as a result of response to injury such that a persistent and excessive wound healing response induces extracellular matrix (ECM) deposition leading to HCC.