Commentary Open Access
Volume 2 | Issue 2 | DOI: https://doi.org/10.33696/cardiology.2.011

Beneficial Effects of Surgical Closure of Atrial Septal Defect Outweigh Potential Complications in Sick Infants

  • 1Nemours Cardiac Center, Alfred I. duPont Hospital for Children, Nemours Children’s Health System, 1600 Rockland Road, Wilmington, DE 19803, USA
  • 2Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University, 11th and Walnut, Philadelphia,PA 19107, USA
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Corresponding Author

Takeshi Tsuda, ttsuda@nemours.org

Received Date: February 10, 2021

Accepted Date: May 18, 2021


Infants and children with isolated atrial septal defect (ASD) usually do not develop clinical signs or symptoms. However, infants with premature birth complicated by chronic lung disease may develop certain problems including respiratory distress, dependency upon supplemental oxygen and/or mechanical ventilation, failure to thrive, and prolonged hospitalization; these are induced largely by excessive pulmonary blood flow through ASD. Although transcatheter approach is less invasive than surgery, its feasibility is often limited by anatomical conditions of ASD and the size of the patients. In these circumstances, surgical closure can be performed safely and effectively even in sick infants to improve clinical status. When transcatheter approach is not feasible, the surgical closure of ASD results in a favorable outcome by eliminating excessive pulmonary blood flow, mitigating the need of positive pressure ventilation more quickly, and promoting better physical growth.


Atrial septal defect (ASD), Infants, Prematurity, Bronchopulmonary dysplasia (BPD), Cardiac surgery, Pulmonary hypertension

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