Journal of Experimental Pathology

Editorial Open Access

Tumor Microenvironment and CAR-T Cell Therapy: Challenges, Breakthroughs, and Future Perspectives

Chenhe Hu , Ying Xue , Shishuo Sun

Chimeric antigen receptor (CAR) T cell therapy has achieved unprecedented success in hematologic malignancies, yet its application in solid tumors remains fraught with challenges. Key barriers include antigen heterogeneity, limited tumor infiltration, and most critically, the profoundly immunosuppressive tumor microenvironment (TME). This editorial synthesizes current research to detail the multifaceted suppressive effects of the TME on CAR-T cells, reviews innovative strategies being developed to overcome these barriers, and discusses the future trajectory of CAR-T therapy for solid tumors.

J Exp Pathol, 2026, Volume 7, Issue 1, p10-11 | DOI: 10.33696/pathology.7.060

Original Research Open Access

Comprehensive Analysis of UPS-6 Expression in ABC and Its Correlation with Recurrence Incidence

Sarah Consalvo , Felix Schicktanz , Sebastian Breden , Ulrich Lenze , Ruediger von Eisenhart-Rothe , Carolin Mogler , Carolin Knebel

Aneurysmal bone cyst (ABC) is a benign but locally aggressive bone lesion. USP6 gene rearrangements have been proposed as a key diagnostic marker, detectable via fluorescence in situ hybridization (FISH). However, its clinical utility and correlation with recurrence remains unclear. This study evaluates USP6 FISH as a diagnostic tool and investigates whether USP6 positivity is associated with an increased recurrence risk. This retrospective study analyzed 87 patients with primary ABC at Klinikum rechts der Isar, Technical University of Munich (1991–2021).

J Exp Pathol, 2026, Volume 7, Issue 1, p1-9 | DOI: 10.33696/pathology.7.059