Journal of Experimental Pathology

Review Article Open Access

Cancer Stem Cells, Together with Mesenchymal Stem Cells and Other Cooperative Cells, Govern the Initiation and Development of Cancer

Gabriella Racchetti, Jacopo Meldolesi

Until the end of last century, the origin and development of cancers were mostly attributed to the proliferation of their active cells, operative in collaboration with non-cancer cells of the patients. In particular, an important role was attributed to cells now recognized as mesenchymal stem cells (MSCs), first considered a few decades ago. Initially, however, the role attributed to these cells was only limited.

Editorial Open Access

Spinal Capillary and Cavernous Haemangiomas in Developmental Age: Our Experience

Anthony Kevin Scafa, Giorgio Santoro, Vito Chiarella, Nicoletta Greco, Massimo Corsini, Manolo Piccirilli

Vascular anomalies are quite common lesions. They are frequently encountered in the pediatric population, being present at birth or developing later, during infancy, childhood, or adolescence. Most of these lesions are benign. Nevertheless, even benign lesions may exhibit significant morbidity without idoneous management [1].

Research Article Open Access

BNT162b2 mRNA COVID-19 Vaccine Elicited Antibody Responses in COVID-19-naïve Subjects

Chin Shern LAU, Soon Kieng Phua, Ya Li Liang, Mei Lin Helen Oh, Tar-Choon Aw

Coronavirus disease 19 (COVID-19) mRNA vaccines have gained international acceptance and have been proven to be safe and effective [1,2]. In a study of 3,950 frontline healthcare workers with no previous laboratory documentation of COVID-19 [3],

Commentary Open Access

News About the Extracellular Vesicles from Mesenchymal Stem Cells: Functions, Therapy and Protection from COVID-19

Jacopo Meldolesi

The present Commentary is a critical follow-up of a previous review about “Extracellular vesicles, news about their role in immune cells: physiology, pathology and diseases”, appeared in Clinical and Experimental Immunology last June 2019 [1].

Commentary Open Access

Mechanistic and Translational Advances Using iPSC-Derived Blood Cells

Christopher S Thom, Stella T Chou, Deborah L French

The human induced pluripotent stem cell (iPSC) technology was developed more than ten years ago and has provided important tools for the mechanistic and cellular interrogation of many diseases [1]. To generate iPSC lines, somatic cells are reprogrammed into cells resembling embryonic stem cells by the overexpression of key transcription factors.

Research Article Open Access

Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate

Kimberly L. Cramer-Morales, Collin D. Heer, Kranti A. Mapuskar, Frederick E.Domann

Epigenetic processes provide a mechanism for integrating metabolic inputs and translating them into various phenotypic outputs [1,2]. Indeed, epigenetic modifiers often require or are inhibited by key citric acid cycle (CAC) metabolites (e.g. succinate,

Commentary Open Access

Arid5a Inroads to Immunity, Inflammation, and Cancer

Kishan Kumar Nyati, Tadamitsu Kishimoto

The immune system is essential to host defense because it senses attacking pathogens and elicits protective immune responses. Although immune responses can protect against pathogens, uncontrolled immune responses cause tissue damage and other pathological consequences through their inflammatory mediators.