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Journal of Cellular Signaling
ISSN: 2692-0638
Specific Subcellular Localization of Phosphoinositide-Specific Phospholipase C enzymes in Different Human Osteosarcoma Cell Lines
The role of signal transduction in cancer progression is well established and actively studied, including in osteosarcoma. The signal transduction pathways involved in the regulation of calcium metabolism are being intensively studied, with particular regard to phosphoinositide-specific phospholipase C (PLC) signaling. This family of enzymes helps to modulate calcium metabolism and is interconnected with additional signaling molecules belonging to different pathways.
J Cell Signal, 2024, Volume 5, Issue 1, p1-9 | DOI: 10.33696/Signaling.5.107MKP-2 Deficiency Leads to Lipolytic and Inflammatory Response to Fasting in Mice
The liver plays a crucial role in maintaining homeostasis for lipid and glucose. Hepatic lipid synthesis is regulated by nutritional signals in response to fasting and refeeding. It is known that overnutrition regulates MAPK-dependent pathways that control lipid metabolism in the liver by activating MAPK phosphatase-2 (MKP-2). Uncertainty still exists regarding the regulatory mechanisms and effects of MKP-2 on hepatic response to fasting.
J Cell Signal, 2024, Volume 5, Issue 1, p10-23 | DOI: 10.33696/Signaling.5.108Monitoring Transcription of miR-15a and miR-124 in Mesenchymal Stem Cells from Adipose Tissue Origin Differentiated into Pancreatic Beta-cells
MicroRNAs are small, noncoding pieces of nucleic acid with the potential to control mRNA translation. These sequences participate in the regulation of cell dynamic growth and differentiation. In this study, the expression of miR-15a and miR-124 was monitored in adipose-derived tissue stem cells committed to pancreatic β cells in vitro over 28 days. In the current experiment, adipose-derived mesenchymal stem cells were incubated in an induction medium to accelerate differentiation toward the endocrine pancreatic lineage for 28 days with a three-stage protocol.
J Cell Signal, 2024, Volume 5, Issue 1, p24-29 | DOI: 10.33696/Signaling.5.109Phorbol-12-Myristate-13-Acetate (PMA) Reactivates Replication from HIV-1 Latency and Induces Jurkat Cell Death
HIV-1 has the capability to establish latency during early infection in CD4+ cells, posing a significant challenge to the efforts aimed at curing HIV-1/AIDS. One extensively explored strategy to address this viral latency is the "shock-and-kill" approach. This involves reactivating viral replication using latency reversal agents (LRAs) to induce the death of infected cells. Regrettably, no LRAs with proven effectiveness have been identified thus far.
J Cell Signal, 2024, Volume 5, Issue 1, p30-40 | DOI: 10.33696/Signaling.5.110Role of Exosomal MicroRNAs in Modulating the Response of Cancer Cells to Paclitaxel Treatment
MicroRNAs (miRNAs) play important roles in gene regulation and have been implicated in various human diseases, including cancer. MiRNAs can be packaged in exosomes and transferred between cells. These exosomal miRNAs regulate intercellular communication and influence almost all aspects of cancer biology, including proliferation, apoptosis, invasion, metastasis, and angiogenesis.
J Cell Signal, 2024, Volume 5, Issue 1, p41-50 | DOI: 10.33696/Signaling.5.111Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.