Journal of Cellular Signaling

Research Article Open Access

One-to-one Benefit Provided by Antioxidants to Cultured Skin Fibroblasts from Friedreich Ataxia Patients

Paule Bénit , Malgorzata Rak , Pierre Rustin

As to better understand and characterize the dramatic differences in antioxidant response of human cells harboring mutations in the frataxin gene responsible for Friedreich's ataxia (FRDA), we studied primary cultures of skin fibroblasts derived from five FRDA patients with different major frataxin gene expansion sizes. Since oxidative stress has been previously established to play a critical role in FRDA, among the many enzymes that may modulate oxidative stress sensitivity, we selected some that have previously been shown to be critical in oxidative stress.

Research Article Open Access

Elevated Interleukin-6 (IL-6) Levels with Ig (G & M) Antibodies in the Recovery Phase of Patients with COVID-19: Indication of Cytokine Storm and Re-infection

John Bolodeoku , Terry Gbaa

The innate immune response to coronavirus disease (COVID-19) by inflammatory cytokines, such as interleukin 6 (IL-6), has been described as an early response, followed by an adaptive immune response with the production of antibodies. IL-6 is produced in response to viral infections and is crucial for the activation of T cells and the differentiation of B cells, which produce antibodies. Immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies are produced during the initial acute period of infection and the recovery period from the period of onset of symptoms.

Review Article Open Access

Obesity Significantly Modifies Signaling Pathways Associated with Bone Remodeling and Metabolism

Ferah Armutcu , Eugene McCloskey , Mehmet Ince

It is obvious that obesity-related diseases are increasing in parallel with the prevalence of obesity, which has reached epidemic proportions worldwide. Cardiovascular disease, multiple cancers, stroke, type 2 diabetes and many other non-communicable diseases are more likely to develop in people living with obesity compared to those living at a healthy weight. In recent years, deeper investigation of the role of multi-organ interaction mechanisms in obesity and related chronic diseases has contributed to the development of new treatment and prevention strategies for obesity and its related-diseases.

Research Article Open Access

Indole Family and Neomycin Sulfate: Inductors of Differentiation in C2C12 and RD cell Lines

Lorena Milanesi , Andrea Vasconsuelo , Lucía Pronsato , Natalia Frattini , Nicolás Blanco

Rhabdomyosarcoma (RMS) is a highly aggressive tumor primarily affecting the pediatric population, that generally originates from a failure in the embryonic differentiation of myogenic precursor cells. Standard treatment involves surgery, chemotherapy and radiation therapy, with a poor prognosis, especially when it spreads to other parts of the body, highlighting the need for new treatment approaches.

Mini Review Open Access

Combating PDAC Drug Resistance: The Role of Ref-1 Inhibitors in Accelerating Progress in Pancreatic Cancer Research

Eyram K. Kpenu , Mark R. Kelley

Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the most lethal solid tumor diagnoses given its limited treatment options and dismal prognosis. Its complex tumor microenvironment (TME), heterogeneity, and high propensity for drug resistance are major obstacles in developing effective therapies. Here, we highlight the critical role of Redox effector 1 (Ref-1) in PDAC progression and drug resistance, focusing on its redox regulation of key transcription factors (TFs) such as STAT3, HIF1α, and NF-κB, which are pivotal for tumor survival, proliferation, and immune evasion.