Journal of Cellular Signaling

Commentary Open Access

F-ATP Synthase Inhibitory Factor 1 in Regulation of Mitochondrial Permeability Transition Pore and Metabolic Reprogramming

Lishu Guo

Mitochondrial permeability transition pore (PTP) plays an important role in mitochondrial physiology and cell fate. Emerging studies highlight PTP forms from F-ATP synthase, but whether F-ATP synthase inhibitory factor 1 (IF1) regulates the activity of PTP is basically unknown. We have recently demonstrated that IF1 interacts with p53-CyPD complex and promotes opening of the PTP, and IF1 is necessary for the formation of p53-CyPD complex.

Commentary Open Access

The Finer Points of Podocyte Sphingolipid Metabolism in Diabetic Kidney Disease

Alla Mitrofanova , Rachel Njeim , Alessia Fornoni

Diabetic kidney disease (DKD) is a common complication of diabetes, characterized by kidney damage. Podocytes are specialized, terminally differentiated cells in the kidney’s filtration barrier that are key responders to the metabolic and environmental changes that occur in diabetes. Change in the function and in the number of podocytes is the main signature of the development and progression of DKD.

Review Article Open Access

Structural Insights into Protein-Ligand Interactions of Small Leucine Rich Repeat Proteoglycans with a Large Number of Binding Partners: An Overview

Norio Matsushima , Hiroki Miyashita , Dashdavaa Batkhishig , Robert H. Kretsinger

Small leucine rich repeat proteoglycans (SLRPs) exist in the extracellular matrix. SLRPs contain tandem arrays of LRRs flanked by cysteine clusters at the both N- and C-termini. The extreme N- and/or C-termini contain low complexity sequences, glycosaminoglycan (GAG) chain and/or sulfated tyrosine residues in some members of SLRPs.

Commentary Open Access

Activation of the 5-hydroxytryptamine Degradation System in Cells and Organ Injury

Jihua Fu

This paper summarizes the research results of Fu et al. on the pathological mechanism of organ injury. A hypothesis was proposed that "organ injury is a consequence of the activation of the 5-hydroxytryptamine degradation system (5DS) axis in cells". The basic composition of the 5DS axis in cells and the principle of its activation leading to cell lesions were determined.

Review Article Open Access

The Human Gut Phageome: Identification and Roles in the Diseases

Mohsen Nabi-Afjadi , Samane Teymouri , Fatemeh Nafe Monfared , Seyed Mostafa Noorbakhsh Varnosfaderani , Hossein Halimi

The human gut is a complex environment that contains a diversity of microorganisms commonly known as the microbiome. Numerous factors influence the composition of human gut bacterial communities, either contributing to homeostasis or the instability associated with a variety of diseases.

Review Article Open Access

Understanding Elongasome Unit of Mycobacterium and its Comparative Analysis with Other Model Organisms

Preeti Jain

The reported incidences of 10.6 million tuberculosis cases worldwide with 1.6 million deaths in 2021 indicate that this disease, caused by Mycobacterium tuberculosis pathogen is difficult to treat and requires exploring newer possible therapeutic interventions. To identify novel drug targets, it is important to understand the basic physiological processes of each pathogen in detail. Cell division is the fundamental physiological process which maintains the replicative state of bacteria.