Journal of Cellular Signaling

Review Open Access

Shared Biology Underlying Benign Endometrial Diseases and Endometrial Cancer: Current Knowledge and Future Prospectives

Yara Aljubran , Warren B. Nothnick

The endometrium is thought to serve as the precursor tissue for diseases of the uterus such as endometrial cancer, adenomyosis, and endometriosis.  More specifically, endometrial glands are proposed to be the source of developing endometrial cancer within the uterine body while ectopic endometrial glands and surrounding stroma which develop within the myometrium give rise to adenomyosis, and those that establish outside of the uterus give rise to endometriosis.

Mini Review Open Access

The LKB1 Axis in Cancer: Upstream Regulation, Downstream Signaling, and Context-Dependent Functions

Vaishali Kaur , Amal Shaharyar , Mannuru Venkateswarlu , Abhishek Atreya , Sneha Bharti , Sanja Medenica , Ashutosh Rai , Pinaki Dutta

Liver kinase B1 (LKB1) is a serine/threonine kinase that serves as a central regulator of cellular energy homeostasis, growth control, polarity, and stress adaptation. Acting as a master kinase, LKB1 activates AMP-activated protein kinase (AMPK) and a family of related kinases, thereby restraining mTORC1 signaling and limiting anabolic, energy-consuming processes.

Review Open Access

Harnessing the Immune Arsenal against Neuroblastoma

Rachel Y. Han , Breanna R. Buhay , Jaeson D. Chin , Austin J. Marrah , Mark R. Wakefield , Yujiang Fang

Neuroblastoma (NB) is one of the most common causes of pediatric cancer mortality. Cancer is well known for its complexity and wide variety of presentations. At its worst, NB presents with early metastasis and resistance to therapies.

Commentary Open Access

Emerging Roles of Phase Separation at Nuclear Envelope

Yu Tang

The nuclear envelope (NE) is the hallmark of eukaryotic cells, serving as a critical physical barrier that compartmentalizes the genome and separates nuclear and cytoplasmic processes to tightly regulate nucleocytoplasmic transport. Biomolecular phase separation, a physicochemical process frequently driven by proteins containing intrinsically disordered regions (IDRs), is a fundamental mechanism governing diverse cellular activities.

Editorial Open Access

Connecting Molecular Regulation to Cellular Function

Alexis Bruce , Skot L. Rodgers , Le Su

Cell signaling is a complex, interconnected system that controls vital cellular processes such as proliferation, post-translational modifications (PTMs), and, ultimately, cell fate, controlling protein degradation and apoptosis. Alterations in these pathways can lead dysregulation.