Despite the health benefits associated with polyphenols, the bioavailability of many polyphenols limits their effects. Problems with poor solubility fast-metabolism and food preparation techniques limit the bioavailability and bioactivity of these dietary micronutrients. Encapsulation of polyphenols has shown to protect and increase bioavailability of these dietary compounds and to enhance their anticancer activity.

Although being a complex pathology with genetic as well as non-genetic etiologies, cancer is characterized by a limited series of hallmarks including energetic metabolism reprogramming.

Laron Syndrome (LS) (OHIM #262500:ICD-10: primary growth hormone insensitivity) is a rare fully penetrant autosomal recessive type of dwarfism caused by exon deletion or mutations of the growth hormone receptor (GH-R) gene. The majority of the mutations are in the extracellular domain of the receptor and few are in the trans membranal or intracellular domain.

Low-molecular weight proteins, cofactors, amino acids, metabolites and many bioactive signaling molecules are filtered through the glomeruli. Evolution has yielded highly conserved pathways in proximal tubule epithelium for the reabsorption of filtered molecules;

Alzheimer’s disease (AD) research has long been dominated with communications regarding the amyloid hypothesis and targeting amyloid clearance through pharmacological therapies from the brain [1].