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Journal of Cellular Immunology
ISSN: 2689-2812
Guardians of Intestinal Homeostasis: Focus on Intestinal Epithelial Cells
The intestinal epithelium not only facilitates the absorption of nutrients, but also plays a pivotal role in guarding intestinal homeostasis and preventing opportunistic gut microbiome invasions. The intestinal epithelial cells have diverse and coordinated regulatory networks that provide intricate lines of defense, in order to maintain the integrity of the intestinal barrier.
J Cell Immunol, 2024, Volume 6, Issue 1, p1-6 | DOI: 10.33696/immunology.6.186Hair Follicle Stem Cells: the Signaling Hub of the Skin
Hair follicle stem cells (HFSCs) are recognized as multipotential stem cells with exceptional proliferative capacity. Their regulatory effect on skin homeostasis is orchestrated through intricate signaling pathways, including Wnt/β-catenin, transforming growth factor-β/bone morphogenetic protein (TGFβ/BMP), Notch, and Hedgehog.
J Cell Immunol, 2024, Volume 6, Issue 1, p7-14 | DOI: 10.33696/immunology.6.187Personalized Neoantigen DNA Cancer Vaccines: Current Status and Future Perspectives
Tumor mutation-derived neoantigens are considered promising targets for cancer immunotherapy. Personalized vaccines have emerged as an approach to deliver neoantigens and thereby trigger the induction of specific T-cell responses that can find and eliminate tumor cells based on the cell-surface presence of neoantigens. To this end, several neoantigen vaccine formats have provided encouraging results in clinical trials, resulting in neoantigen immunogenicity and clinical benefit.
J Cell Immunol, 2024, Volume 6, Issue 1, p15-24 | DOI: 10.33696/immunology.6.188Essentials of CAR-T Therapy and Associated Microbial Challenges in Long Run Immunotherapy
Chimeric antigen receptor (CAR)-T cell therapy has shown potential in improving outcomes for individuals with hematological malignancies. However, achieving long-term full remission for blood cancer remains challenging due to severe life-threatening toxicities such as limited anti-tumor efficacy, antigen escape, trafficking restrictions, and limited tumor invasion. Furthermore, the interactions between CAR-T cells and their host tumor microenvironments have a significant impact on CAR-T function.
J Cell Immunol, 2024, Volume 6, Issue 1, p25-50 | DOI: 10.33696/immunology.6.189Mechanism, Challenges, and Progresses of Chimeric Antigen Receptors T-cell Cancer Therapy
Cancer is a deadly disease and affects everyone at any level of age. Many people lose hope once they are diagnosed with cancer. This is because there is no effective treatment for it. Till the end of the 19th century, researchers across the world were eager to design effective remedies for this decapitating phenomenon and designed so many interventions even though nothing is compensatory for a malignant tumor; in some cases, the side effects overwhelm the benefits.
J Cell Immunol, 2024, Volume 6, Issue 1, p51-63 | DOI: 10.33696/immunology.6.190Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.