Journal of Cellular Immunology

Commentary Open Access

Live Biotherapeutic Salmonella-IL2 (Saltikva) Plus FOLFIRINOX for Stage IV Metastatic Pancreatic Ductal Adenocarcinoma – Implications of a Phase 2 Clinical Trial

Daniel A. Saltzman , Petr Kavan , Lance Augustin , Janet Schottel , James T. Lee , Jordan Moradian , Eddie Moradian , Gerald Batist

Salmonella-IL2 is an attenuated Salmonella Typhimurium strain carrying the human gene for IL-2. When orally administered in preclinical trials, the bacterium colonizes tumors and locally releases IL-2, triggering immunologically-mediated tumor cell killing without untoward side effects. In addition, extensive preclinical studies and a human phase I trial demonstrated robust NK cell subset population surge with oral administration of Salmonella-IL2.

Brief Report Open Access

Suppression of New Metastases with Saltikva in a Phase II Clinical Trial: A Potential Signal of Immune Memory in Metastatic Pancreatic Ductal Adenocarcinoma

Gerald Batist , Jordan Moradian , Eddie Moradian , Daniel A. Saltzman

Metastatic pancreatic ductal adenocarcinoma (mPDAC) remains one of the most lethal solid tumors, with poor survival despite modern chemotherapy. Traditional efficacy metrics such as objective response rate (ORR) and RECIST-defined progression-free survival (PFS) may incompletely capture the biologic effects of immunotherapy, particularly therapies designed to induce durable systemic immune surveillance rather than immediate cytoreduction.

Review Article Open Access

Understanding the Mechanistic Connection between Dysbiosis and Polyamine Regulation in Oral and Intestinal Inflammation– Role of Tregs and Th17 Cells

Pushpa Pandiyan

Periodontitis and inflammatory bowel disease (IBD) are chronic inflammatory conditions driven by dysbiotic microbial communities that subvert host mucosal immunity. Central to the immunopathology of both diseases is the disruption of the balance between regulatory T cells (Tregs) and T helper 17 (Th17) cells, an equilibrium that governs tissue homeostasis versus inflammatory destruction. Polyamines, principally putrescine (PUT), spermidine (SPD), and spermine (SPN), are emerging as critical immunometabolic regulators that modulate the plasticity and functional identity of both cell populations.

Opinion Article Open Access

B cells are Essential for Memory T cell Development in Germinal Centers

Gongyi Zhang

Nature recently listed 20 major T cell milestones since the early breakthroughs of Drs. Jacques Miller and Max Cooper. However, to make the story more complete, several key discoveries may need to be mentioned. One of the major missing episodes is the discovery of the bone marrow in mice as the origin of T and B cells, revealed by Dr. Henry Claman and his colleagues. The complete absence of the critical role of B cells in the final differentiation of T cells into memory lineages could be a major oversight in modern immunology. In this short essay.

Opinion Article Open Access

A Multidisciplinary Framework for the Management of Serious Adverse Events from Modern Anticancer Therapies

Saqib Abbasi , Nina Mathew , Nanuli Gvazava , Daniel R. Tilden , Anjulie Quick , Aiman Zafar , Jennifer Klemp , Adela R. Cardones , Jason Sokol , Leigh Eck , Weijing Sun

The rapid expansion of immune checkpoint inhibitors, immune effector-cell and T-cell-engaging therapies, Antibody-Drug Conjugates (ADCs), and molecularly targeted agents has transformed both clinical research and standard oncology care. These advances have improved survival across many malignancies, yet they have also introduced a heterogeneous spectrum of adverse events that may be inflammatory, on-target, off-tumor, payload-related, or pharmacologic. Toxicities vary in onset and urgency, may emerge after therapy has stopped, and can affect virtually any organ system [1]. Safe treatment therefore increasingly depends on coordinated expertise that extends beyond the traditional scope of medical oncology.