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Journal of Cellular Immunology
ISSN: 2689-2812
Targeting Monocyte Abnormalities in Systemic Lupus Erythematosus through Omics-Based Drug Repurposing
Systemic Lupus Erythematosus (SLE) is a complex disease marked by extensive immune system dysfunction, culminating in a diverse spectrum of clinical phenotypes of varying severity. Despite the significant advancements in elucidating the pathogenesis of the disease, the management of SLE remains largely empirical with attainment of low disease activity and remission targets being an infrequent outcome among patients.
J Cell Immunol, 2024, Volume 6, Issue 3, p113-116 | DOI: 10.33696/immunology.6.196Homology-Independent Targeted Insertion (HITI) for Therapeutic T-Cell Engineering
In this commentary we discuss our recent work on delivering an anti-GD2 CAR (chimeric antigen receptor) via homology independent targeted insertion (HITI) using the CRISPR/Cas9 technology. HITI relies on Non-Homologous End Joining (NHEJ) that is predominantly exploited by both dividing and non-dividing cells to repair double stranded DNA breaks (DSBs). We explore considerations when using HITI based strategies. Furthermore, we discuss a method for post-HITI CRISPR EnrichMENT (CEMENT) within the context of large-scale clinical manufacturing of non-viral CAR-T cells.
J Cell Immunol, 2024, Volume 6, Issue 3, p117-120 | DOI: 10.33696/immunology.6.197The Aryl Hydrocarbon Receptor as a Possible Novel Immunotherapy Target in Myeloma
Epidemiologic studies have demonstrated a possible association between exposure to environmental aromatic hydrocarbons and the development of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). These aromatic hydrocarbons bind the aryl hydrocarbon receptor (AHR) expressed by plasma cells that seem to promote development and survival of malignant cells.
J Cell Immunol, 2024, Volume 6, Issue 3, p121-124 | DOI: 10.33696/immunology.6.198Evolution of the Classification and Management of Smoldering Multiple Myeloma
The evolving molecular landscape of Smoldering Multiple Myeloma (SMM) has underscored its complex nature and the urgent need for more refined diagnostic and treatment strategies. With an increased risk of progression to Multiple Myeloma (MM), it has become important to identify patients at the highest risk of progression for interception strategies. Risk evaluation has been a constantly moving target with rapidly changing approaches to classification being based predominantly based on imaging and biochemical data thus far.
J Cell Immunol, 2024, Volume 6, Issue 3, p125-139 | DOI: 10.33696/immunology.6.199Association of Smoking and Crohn's Disease: An Update
The relationship between smoking and inflammatory bowel disease (IBD), which has been widely studied for years, is complex and different in Crohn's disease (CD) and ulcerative colitis (UC). The negative effect on CD, not only on disease progression and post-surgical recurrence, but also on post-surgical complications after intestinal resection, on its influence on the reservoir and on the modification of the natural evolution of CD towards fistulizing and stenosing forms, makes a proper approach to the problem imperative.
J Cell Immunol, 2024, Volume 6, Issue 3, p140-147 | DOI: 10.33696/immunology.6.200Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.