Journal of Cellular Immunology

Review Article Open Access

T lymphocytes in Aging: CD38 as a Novel Contributor between Inflammaging and Immunosenescence

Wendolaine Santiago-Cruz , Fabio García-García

CD38 is a transmembrane protein expressed in immune and non-immune cells involved in nicotinamide adenine dinucleotide (NAD⁺) consumption, cyclic Adenosine Diphosphate Ribose (cADPR) generation, and calcium mobilization by its enzymatic activity. It also promotes an activated and pro-inflammatory phenotype in immune cells. Senescence is a cellular state of cell growth arrest accompanied by senescent-associated secretory phenotype (SASP) products.

Mini Review Open Access

Cytoreductive Nephrectomy Following Immunotherapy: Evolution, Pearls, and Pitfalls of Treatment

Laura E. Davis , Adam Calaway , Eric A. Singer , Shawn Dason

Renal Cell Carcinoma (RCC) is among the most frequently diagnosed malignancies in both genders with over 81,000 estimated cases in 2024. Despite increasing incidence of renal cell carcinomas <4 cm, up to 1/3 of patients diagnosed with RCC exhibit metastatic disease (mRCC) at time of diagnosis. Cytoreductive nephrectomy (CN), a procedure which encompasses the surgical removal of the primary tumor in patients with metastatic disease

Review Article Open Access

Chemokines and Their Receptors in Hepatitis B Virus Infection: A Comprehensive Review

Jiezuan Yang , Dan Cao , Ruiqi Tang , Xuefen Li

Chemokines, a group of small cytokines, play a central role in the pathogenesis of viral hepatitis by regulating the migration, proliferation, and activation of lymphocytes. These chemotactic factors of immune cells are directly involved in various cellular biological activities, including cell adhesion, angiogenesis, and diffusion. The aberrant expression of lymphocyte chemokines and their receptors is closely related to the biological behavior of host immune cells as well as the specific and non-specific immune responses to viral infections and may influence the prognosis of viral diseases.

Case Report Open Access

Clinical Case Report of CAR-T Therapy of Patient with Refractory Burkitt's Lymphoma

Tatiana Mikhailovna Doroshenko , Olga Alexandrovna Kalenik , Ihar Mikhalaevich Seviaryn , Kataryna Yureuna Zharkova , Denis Alexandrovich Davydov , Anna Sergeevna Portyanko , Alena Vladimirovna Sukalinskaya , Sergey Lvovich Polyakov , Natalia Eugenevna Konoplya

Approximately 20% of adult patients with Burkitt's lymphoma (BL) have relapsed/refractory disease, which is characterized by poor overall survival (OS) and virtually no therapeutic options after failure of two lines of chemotherapy, due in part to the peculiarities of tumor cell biology. Improved treatment strategies are an unmet need for these patients. There have been individual attempts to use chimeric antigen receptor (CAR)-T therapy in this patient population using anti-CD19, CD20, and CD22 cells.

Research Article Open Access

Upregulated Gene Expression of Histone Deacetylases (HDAC) 1, 2, and 11 in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients

Samaneh Enayati , Mozhgan Moharamoghli , Ali Farazmand , Vahideh Hassan-Zadeh , Shiva Poursani , Elham Madreseh , Maryam Akhtari , Masoumeh Akhlaghi , Elham Farhadi , Asghar Hajiabbasi , Ahmadreza Jamshidi , Mahdi Mahmoudi

The histone deacetylase (HDAC) family consists of epigenetic modifiers that demonstrate anti-inflammatory activities, and hence they might have a substantial role in auto-inflammatory disorders including rheumatoid arthritis (RA). Therefore, the aim of this study is to investigate the expression of HDAC1, HDAC2, and HDAC11 genes in peripheral blood mononuclear cells (PBMCs) of RA cases compared to healthy controls.