Archives of Clinical Pediatrics

Commentary Open Access

Association between Cytomegalovirus Infection and Autism Spectrum Disorder

Maria Beatriz Tavares Camacho Pereira

Autism spectrum disorder (ASD) is a neurological and developmental disorder that generally appears before the age of 3 but can be diagnosed at any age. It is more often in boys than girls and the prevalence is not affected by race. It impacts the normal development of the brain and affects the social interaction, communication skills and cognitive function.

Arch Clin Pediatr, 2025, Volume 2, Issue 1, p1-3 | DOI: 10.33696/Pediatrics.2.006

Editorial Open Access

Beyond the Single Gene: Rethinking Diagnosis in Rare Pediatric Disorders Through Integrative Genomics 

María Paula Rengifo Mosquera , Lina Johanna Moreno Giraldo

In pediatric medicine, the most powerful stories often arise not from common conditions, but from the outliers—the children whose clinical constellations challenge what we think we know about inheritance, phenotype, and disease mechanisms. The report in this issue of Pediatrics describes one such case: a 6-year-old boy presenting with multiple osteochondromas, short stature, and dysmorphic features, in whom next-generation sequencing revealed a single heterozygous pathogenic variant in SMARCAL1, the gene classically associated with Schimke immuno-osseous dysplasia (SIOD). 

Arch Clin Pediatr, 2025, Volume 2, Issue 1, p4-5 | DOI: 10.33696/Pediatrics.2.007