Archives of Cancer Biology and Therapy

Commentary Open Access

Forces, Chromosomal Configurations, and Carcinogenesis: Towards Another Therapeutic Approach

Michael M. Lieber

Various types of forces, such as cohesive and adhesive forces, are involved in physical and biological processes. Many of these processes appear to have developmental features through different scales of nature, and such processes may reflect a universal dynamic of accommodation involving the universal dimensional constants

Commentary Open Access

Influence of Clinical Risk Factors on Outcomes in Men with Stage I Non-Seminomatous Germ Cell Tumor Undergoing Robot-Assisted Retroperitoneal Lymph Node Dissection

Dora Jericevic , Jacob Taylor , William C. Huang

Retroperitoneal lymph nodes are often the first landing site of metastatic disease in men with testicular cancer. Primary retroperitoneal lymph node dissection (RPLND) for clinical stage I NSGCT can accurately surgically stage patients who may have nodal micrometastases, and in some cases, can serve as the primary therapy when volume of metastasis is low.

Short Communication Open Access

Synthetic Lethal Drug Combinations Targeting Proteasome and Histone Deacetylase Inhibitors in TP₅₃-Mutated Cancers

Shaoli Das , Xiang Deng , Kevin Camphause , Uma Shankavaram

Tumors harboring mutations in certain oncogenes are often dependent on activation of certain pathways which becomes essential for the survival of the cancer cells. This condition is formally known as synthetic lethality, a state when simultaneous loss of two genes is lethal to a cancer cell, while the loss of the individual genes is not.

Short Communication Open Access

VA-Radiation Oncology Quality Surveillance Program: Enhancing Quality Measure Data Capture, Measuring Quality Benchmarks and Ensuring Long Term Sustainability of Quality Improvements in Community Care

Evangelia Katsoulakis , Rishabh Kapoor , John Park , Christina Chapman , Abhi Solanki , Lindsay Puckett , Rebecca Hagan , William Sleeman , Jatinder Palta , Michael Hagan

High quality cancer care improves patient survival and quality of life. Radiation plays an important role in cancer management, given that over 50% of all cancer patients receive radiation therapy as either a primary treatment or for palliation. Ensuring quality of radiotherapy specifically, is therefore important to achieving optimal patient outcomes.

Short Communication Open Access

Impact of Cisplatin Dosing Regimens on Mammary Tumor Growth in an Animal Model

James A. Koziol , Theresa J. Falls , Jan E. Schnitzer

In a recent paper, we introduced a variant of the classical Simeoni tumor growth model, and illustrated its value in assessing tumor growth in a reproducible mouse model for mammary tumors. Our modification consisted of incorporating delay differential equations in the mathematical formulation of the Simeoni model, to represent the delay in drug action often observed under chemotherapeutic or immunotherapeutic regimens.

Research Article Open Access

Uniportal VATS Lobectomy for Lung Cancer: Feasibility and Cost Effectiveness in a Single Center Experience

Crucitti Pierfilippo , Longo Filippo , Tacchi Giovanni , Manca Paolo , Frasca Luca , Carannante Filippo , Spoto Silvia , Citarella Fabrizio , Tonini Giuseppe

In last decades, video-assisted thoracic surgery (VATS) together with robotic-assisted thoracic surgery (RATS) can be considered the biggest innovation in thoracic surgery. This approach drastically changed the way of performing surgical operations, improving patient’s outcome undergoing thoracic surgery.