Commentary Open Access
Volume 2 | Issue 1 | DOI: https://doi.org/10.33696/cancerbiology.2.016

Forces, Chromosomal Configurations, and Carcinogenesis: Towards Another Therapeutic Approach

  • 1Genadyne Consulting, Berkeley, California, USA
+ Affiliations - Affiliations

Corresponding Author

Michael M. Lieber, michaellieber@juno.com

Received Date: November 04, 2020

Accepted Date: January 18, 2021


Previous studies of in vitro and in vivo morphogenesis may suggest a more inclusive principle governing biological processes. In this regard, methylglyoxal (MG) in very low, non-toxic concentrations and ascorbic acid have been shown to promote in vitro morphogenesis in various types of plants. Forces of cohesion and adhesion might be involved in such development. These are conveyed through the electronic desaturation of protein by means of MG and ascorbic acid. In low concentration, MG with ascorbic acid or ascorbate might induce adhesion within the histone proteins making up a part of the chromosomes in mammals. As proposed, this may induce specific regions of gene inactivation, through heterochromatization, and specific chromosomal re-configurations, that would be needed for the completion of stable development, by means of chromosome stabilization via differential adhesion, and the consequent prevention of carcinogenesis. Such re-configurations may reflect accommodation to cohesive and adhesive stress. Forces, including those of adhesion and cohesion, may reflect the deep guidance of the universal constants of physics, which would occur through a constant, regenerative-defining component of those constants. The component would be to define or geometrically guide the regeneration of stability, coherence, and constancy in nature at various scales, through dynamic accommodation, which would be most manifest in biological processes. Awareness and elaboration of such may open up new therapeutic vistas, especially with regard to the treatment of cancer.


Accommodation; Adhesion; Ascorbic acid; Biology; Callus; Carcinogenesis; Chromosome; Cohesion; Completion; Concentration; Configurations; Correspondence; Development; Dimensional/dimensionless Constants; Evolutionary; Force; Heterochromatin; Methylglyoxal; Morphogenesis; Physics; Principle; Stability; Stress; Therapeutic; Unifying; Universal

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