Journal of Diabetes and Clinical Research

Riyasat Ali

Department of Pharmacology and Pharmaceutics

University of Houston

USA

Academic Editor

Biography

Dr. Riyasat Ali has been working as a Research Scientist in the Hematology Division of the Department of Internal Medicine at UT Southwestern Medical Center, Dallas, USA. Before joining here, Dr. Ali worked as a research assistant professor in the Department of Pharmacology and Pharmaceutics at the College of Pharmacy, University of Houston, TX, USA. Dr. Ali completed his Ph.D. (in immunology and peptide-based vaccine design) from the Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India, in January 2013. During his thesis work, Riyasat has developed a peptide-based vaccine against Yersinia pestis. Also, he worked on B- and T-cell epitope mapping of the YscF antigen of Y. pestis.

During his scientific journey, Dr. Ali has worked to understand the pathogenesis of type 1 diabetes (T1D) by exploiting the antigen-specificities and biology of the anti-beta-cell CD4 and CD8 T lymphocyte pools in mouse models of the NOD background, and by using DEC-205 (a dendritic cell receptor) to induce immune tolerance in pre-clinical models. Moreover, Dr. Ali explored the roles of TGF-beta signaling and T regulatory cells in the induction of leprosy disease, and angiotensin receptor-mediated (AT2R) reversal of kidney pathologies. 

Currently, Dr. Ali is working on breast cancer immunotherapy in preclinical animal models and patients with hormone receptor-positive breast cancer. Dr. Ali is trying various combinations of chemotherapy, hormone therapy, and immunotherapy to improve existing therapeutic regimens. Moreover, he is involved in a variety of other academic activities, including presenting research papers and attending scientific conferences, meetings, and symposia, and reviewing research papers for a variety of scientific journals of interest. Also, Dr. Ali is actively involved in making scientific collaborations to understand the subject in depth.

Research Interest

Cancer Immunotherapy, T cell biology, diabetes immunology, and kidney inflammation.