Department of Pharmacology and Pharmaceutics
University of Houston
Dr. Riyasat Ali has been working as a Research Associate in the Department of Pharmacology and Pharmaceutics, College of Pharmacy, University of Houston, TX, USA. Before joining here, Dr. Ali has worked as a postdoctoral fellow in the Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA. Dr. Ali completed his Ph.D. (in immunology and peptide-based vaccine design) from the Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India, in January 2013. During his thesis work, Riyasat has developed a peptide-based vaccine against Yersinia pestis. Also, he worked on B and T cell epitope mapping on the YscF antigen of Y. pestis.
During his postdoctoral training, Dr. Ali has been working to understand the pathogenesis of Type 1 Diabetes (T1D) by exploiting the antigenic specificities and biology of the anti-beta cells CD4 and CD8 T lymphocyte pool in mouse models of NOD background. Also, the possibilities of the use of diabetogenic T cell receptors (TCRs) to generate a putative humanized mouse model for T1D have been extensively studied. Moreover, possibilities for exploring dendritic cells (DCs) to generate antigen/peptide-specific tolerance have also been studied. Moreover, he is working on DEC-205 (a receptor on dendritic cells) mediated antigen delivery to induce tolerance in T1D studies. Also, Dr. Ali is using DEC-205 mediated antigen delivery to induce HIV peptide/antigen-specific immune response when administered along with suitable adjuvants in mice, and this strategy can be used in a number of other infectious diseases.
Currently, Dr. Ali is working on kidney inflammation, hypertension, and diabetes associated nephropathy. In addition to the bench work, he is also involved in a variety of other academic activities like presenting research papers and attending scientific conferences, meetings and symposia; and also reviewing research papers for a variety of scientific journals of interest. Also, Dr. Ali is actively involved in making scientific collaborations to understand the subject in depth.
Kidney inflammation, hypertension, and diabetes associated nephropathy
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