Journal of Diabetes and Clinical Research

Riyasat Ali

Department of Pharmacology and Pharmaceutics

University of Houston

USA

Academic Editor

Biography

Dr. Riyasat Ali has been working as a Research Associate in the Department of Pharmacology and Pharmaceutics, College of Pharmacy, University of Houston, TX, USA. Before joining here, Dr. Ali has worked as a postdoctoral fellow in the Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA. Dr. Ali completed his Ph.D. (in immunology and peptide-based vaccine design) from the Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India, in January 2013. During his thesis work, Riyasat has developed a peptide-based vaccine against Yersinia pestis. Also, he worked on B and T cell epitope mapping on the YscF antigen of Y. pestis.

During his postdoctoral training, Dr. Ali has been working to understand the pathogenesis of Type 1 Diabetes (T1D) by exploiting the antigenic specificities and biology of the anti-beta cells CD4 and CD8 T lymphocyte pool in mouse models of NOD background. Also, the possibilities of the use of diabetogenic T cell receptors (TCRs) to generate a putative humanized mouse model for T1D have been extensively studied. Moreover, possibilities for exploring dendritic cells (DCs) to generate antigen/peptide-specific tolerance have also been studied. Moreover, he is working on DEC-205 (a receptor on dendritic cells) mediated antigen delivery to induce tolerance in T1D studies. Also, Dr. Ali is using DEC-205 mediated antigen delivery to induce HIV peptide/antigen-specific immune response when administered along with suitable adjuvants in mice, and this strategy can be used in a number of other infectious diseases.

Currently, Dr. Ali is working on kidney inflammation, hypertension, and diabetes associated nephropathy. In addition to the bench work, he is also involved in a variety of other academic activities like presenting research papers and attending scientific conferences, meetings and symposia; and also reviewing research papers for a variety of scientific journals of interest. Also, Dr. Ali is actively involved in making scientific collaborations to understand the subject in depth.

Research Interest

Kidney inflammation, hypertension, and diabetes associated nephropathy