Review Article Open Access
Volume 4 | Issue 2

SARS-CoV-2 Infection: The Viral Arms Race and Pattern- Recognition Receptors

  • 1Department of Immunology, School of Basic Medicine, Chongqing Medical University, Chongqing, China
  • 2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
+ Affiliations - Affiliations

*Corresponding Author

Qi Liu, qi.liu@utsouthwestern.edu

Received Date: February 04, 2022

Accepted Date: March 21, 2022


Novel virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is highly infectious, which often causes severe acute and long-term illness, resulting in an increased rate of mortality and morbidity. Despite human cells being equipped with an antiviral innate immune system, SARS-CoV-2 quickly spread worldwide. A number of Pattern-Recognition Receptors (PRRs) are employed by cells to detect coronavirus infection, and timely interferon responses is immensely effective against SARS-CoV-2. However, the virus is also able to disarm the cell, attacking interferon-associated signaling pathways on multiple levels. Here we systematically analyze the complicated interactions between SARS-CoV-2 proteins and the host interferon signaling system, highlighting the role of cytosolic events in COVID-19 pathogenesis, and summarize a few antiviral pharmaceutic candidates that are potentially able to reduce morbidity and mortality of COVID-19.

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