Mini Review Open Access
Volume 2 | Issue 4 | DOI: https://doi.org/10.33696/Signaling.2.057

ZBP1, a dsRNA Sensor for Cell Death and Inflammation

  • 1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China
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Corresponding Author

Wei Mo, wmo@xmu.edu.cn

Received Date: July 10, 2021

Accepted Date: September 29, 2021


ZBP1 has aroused a wide interest since it was identified as the first cytosolic dsDNA sensor ahead of the finding of cGAS in 2013. However, the investigations on ZBP1 declined when researchers found the binding of ZBP1 with dsDNA is not absolutely required for the activation of innate response. Recently, the significance of ZBP1 was reemphasized as a key regulator of innate immunity. Here we reviewed the emergence of evidence on how ZBP1 promotes cell death and inflammation upon physiological and pathological challenges.


ZBP1, Cell death, Inflammation, Cytosolic NA sensor

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