ZBP1 has aroused a wide interest since it was identified as the first cytosolic dsDNA sensor ahead of the finding of cGAS in 2013. However, the investigations on ZBP1 declined when researchers found the binding of ZBP1 with dsDNA is not absolutely required for the activation of innate response. Recently, the significance of ZBP1 was reemphasized as a key regulator of innate immunity. Here we reviewed the emergence of evidence on how ZBP1 promotes cell death and inflammation upon physiological and pathological challenges.
ZBP1, Cell death, Inflammation, Cytosolic NA sensor