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Journal of AIDS and HIV Treatment

ISSN: 2688-7436

Original Research Open Access
Volume 7 | Issue 1 | DOI: https://doi.org/10.33696/AIDS.7.061

The Outcome of Operation Triple Zero Clubs on Viral Load Outcomes among Adolescents Living with HIV: An Interventional Study of ICHSSA-2 Project in Lagos State

Felix N. Iwuala1, Elijah O. Idoko1,*, Doreen Magaji2, Esther O. Brodrick-Shehu1, Inioluwa O. Johnson1, Ayotunde Akinwumi-Omidiji1, Olakunle Osinowo1, Ayokanmi J. Mobereade1, Gbadegesin O. Alawode1, Chika Obiora-Okafo2, Moses Katbi2, Jemeh Pius2, Tosin Idaboh2, Omosalewa Oyelaran2, Bayo M. Onimode2, Olugbenga Asaolu2, Ughwereoghene K. Omo-Emmanuel2
  • 1Association for Reproductive and Family Health, ICHSSA-2 Project, Lagos, Nigeria
  • 2Office of HIV & TB, United States Agency for International Development (USAID), Abuja, Nigeria
+ Affiliations - Affiliations

Corresponding Author

Elijah O. Idoko, idoko.e@arfh-ng.org

Received Date: January 15, 2025

Accepted Date: May 06, 2025

Citation:

Iwuala FN, Idoko E, Magaji D, Brodrick-Shehu EO, Johnson IO, Akinwumi-Omidiji A, et al. The Outcome of Operation Triple Zero Clubs on Viral Load Outcomes among Adolescents Living with HIV: An Interventional Study of ICHSSA-2 Project in Lagos State. J AIDS HIV Treat. 2025;7(1):54-64.


Copyright: © 2025 Iwuala FN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: In Nigeria, the total number of AIDS-related deaths among children and adolescents was 16,200 in 2020. The Integrated Child Health and Social Services Award 2 (ICHSSA-2) project supports Operation Triple Zero (OTZ) clubs in 13 health facilities in Lagos State with support from PEPFAR through the United States Agency for International Development (USAID). The initiative aimed at ensuring zero missed appointments, zero missed drugs, and zero viral load among adolescents living with HIV (ALHIV).

Methodology: A quasi-experimental study design was used to evaluate the impact of the OTZ intervention on viral suppression rates among 237 adolescents aged 10–20 years enrolled in OTZ clubs from October 2021 to September 2023. Data from the OTZ club register and electronic medical records from the health facilities were used. The study analyzed data from 237 ALHIV enrolled on OTZ clubs between 12 to 24 months. Chi-square statistics was used to compare proportional differences in viral load change using STATA version 14 at p<0.05.

Results: The mean age of participants was 16 ± 2.5 years comprising 55% females and 45% males. The baseline data showed that 80.2% (Female-81.5%; Male- 78.5%) of participants had suppressed viral load. The viral load suppression performance increased to 95.4% (Female 95.4%; Male- 95.3%). Overall, there was 15.2% increase in viral load suppression with 16.8% and 13.9% among male and female participants respectively. Further analysis showed an increase in proportion of those with undetectable viral load (<20 copies/ml) from 40% at baseline to 70% at the end of this study.

Conclusion: The study revealed that OTZ club intervention has proven effective in improving retention and viral load suppression among ALHIV. Government and Implementing Partners might consider prioritizing and sustaining the implementation of OTZ club intervention. Scaling up OTZ club intervention could improve viral suppression among adolescents.

Keywords

HIV, Operation Triple Zero, Adherence, ART, Adolescents living with HIV

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