Commentary Open Access
Volume 1 | Issue 4 | DOI: https://doi.org/10.33696/Gastroenterology.1.016

The Dual Role of Macrophages during Hepatitis B Infection

  • 1Division of Chronic Inflammation and Cancer, German Cancer Research Centre (DKFZ), 69120, Heidelberg, Germany
  • 2INSERM, U1052, Cancer Research Centre of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard (CLB), Lyon, France
+ Affiliations - Affiliations

Corresponding Author

Faure-Dupuy Suzanne, faure-dupuy@dkfz.de

Received Date: October 05, 2020

Accepted Date: October 20, 2020


Macrophages, and related cells, are key players of the innate immune response against pathogens. However, they can also be implicated in pathogen persistence and associated pathogenesis. Hereby, we discussed the dual role of liver macrophages during Hepatitis B virus infection. Whereas pro-inflammatory macrophage secretions can inhibit the viral infection, modulation of macrophages phenotype by the virus favour the establishment and maintenance of the infection.


Hepatitis B virus, Pro-inflammatory macrophage, Anti-inflammatory macrophage, Immune modulation, Kupffer cells, IL-1beta, Primary cells, Anti-viral

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