Commentary Open Access
Volume 1 | Issue 4 | DOI: https://doi.org/10.33696/Gastroenterology.1.016
The Dual Role of Macrophages during Hepatitis B Infection
Suzanne Faure-Dupuy1,*, Julie Lucifora2, David Durantel2
- 1Division of Chronic Inflammation and Cancer, German Cancer Research Centre (DKFZ), 69120, Heidelberg, Germany
- 2INSERM, U1052, Cancer Research Centre of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard (CLB), Lyon, France
Corresponding Author
Faure-Dupuy Suzanne, faure-dupuy@dkfz.de
Received Date: October 05, 2020
Accepted Date: October 20, 2020
Faure-Dupuy S, Lucifora J, Durante D. The Dual Role of Macrophages during Hepatitis B Infection. Arch Gastroenterol Res. 2020; 1(4): 89-94.
Copyright: © 2020 Faure-Dupuy S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Macrophages, and related cells, are key players of the innate immune response against pathogens. However, they can also be implicated in pathogen persistence and associated pathogenesis. Hereby, we discussed the dual role of liver macrophages during Hepatitis B virus infection. Whereas pro-inflammatory macrophage secretions can inhibit the viral infection, modulation of macrophages phenotype by the virus favour the establishment and maintenance of the infection.
Keywords
Hepatitis B virus, Pro-inflammatory macrophage, Anti-inflammatory macrophage, Immune modulation, Kupffer cells, IL-1beta, Primary cells, Anti-viral
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