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Archives of Cancer Biology and Therapy

ISSN: 2692-8302

Case Report Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.33696/cancerbiology.3.028

Pseudoaneurysm of the Breast after Diagnostic Core-Needle Biopsy: Contextualizing Impact on Treatment

Caroline Lommer1, Brandy M. Griffith2, Ashley P Davenport3, Gary Tozbikian4, Doreen M. Agnese5, Sara P. Myers5,6,*
  • 1The Ohio State University College of Medicine, Columbus, OH, USA
  • 2Division of Breast Imaging, Department of Radiology, The Ohio State University Wexner Medical Center and James Cancer Hospital, Columbus, OH, USA
  • 3Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA
  • 4Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA
  • 5Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center and James Cancer Hospital, Columbus, OH, USA
  • 6CATALYST, Center for the Advancement of Team Science, Analytics, and Systems Thinking in Health Services and Implementation Science Research, College of Medicine, The Ohio State University, Columbus, OH, USA
+ Affiliations - Affiliations

Corresponding Author

Sara Myers, Sara.Myers@osumc.edu

Received Date: June 11, 2025

Accepted Date: July 15, 2025

Citation:

Lommer C, Griffith BM, Davenport AP, Tozbikian G, Agnese DM, Myers SP. Pseudoaneurysm of the Breast after Diagnostic Core-Needle Biopsy: Contextualizing Impact on Treatment. Arch Cancer Biol Ther. 2025;3(1):5–9.


Copyright: © Lommer C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This case report considers an iatrogenic pseudoaneurysm (PSA), a rare event occurring in fewer than 2% of patients, after a core-needle biopsy of the breast in a 46-year-old with stage IIIC triple negative invasive breast carcinoma on preoperative chemoimmunotherapy with the PD-1 inhibitor pembrolizumab. A post-biopsy MRI (magnetic resonance imaging) demonstrated a well-defined, contrast-enhancing lesion with pulsatile flow consistent with PSA. Multidisciplinary discussions addressed PSA management and timing of immunotherapy, given the potential association of PD-1/PD-L1 inhibitors with the progression of vascular anomalies. Although breast PSA is uncommon, this complication warrants investigation in light of the increasing application of immunotherapies, which may mediate vascular inflammation.

Keywords

Pseudoaneurysm, Breast, Ultrasound, Pembrolizumab, Biopsy

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