Postmenopausal hyperhidrosis (PMH) is an important differential diagnosis to vasomotor symptoms (VMS) in menopause. The objective is to describe the differences in clinical presentation and treatment of the two conditions.

Patients suffering from PMH represent a unique cohort of patients with primary hyperhidrosis and should therefore not be treated in the same way as those displaying VMS during menopause. Postmenopausal hyperhidrosis is a neglected differential diagnosis to the common VMS in menopause. The two diagnoses have similarities but also distinct differences in presentation. However, the treatments of the diagnoses differ substantially. This review explains the differences in clinical presentation and treatments and suggests botulinum toxin type B in the treatment of vasomotor symptoms due to anti-oestrogen therapy.