The Yazidi population has faced systematic persecution, culminating in the 2014 genocide by the so-called Islamic State (IS). This commentary focuses on the impact of collective trauma on Yazidi mental health, focusing on transgenerational trauma, gender-specific experiences, and culturally adapted therapeutic interventions. The discussion highlights the importance of interdisciplinary approaches that consider cultural and socio-political contexts in the treatment of Yazidi survivors. Addressing these complex mental health challenges requires a holistic framework that integrates psychological, social, and legal support mechanisms.