Commentary Open Access
Glucagon-like Peptide-1 Receptor Agonists in Treating Diabetes Mellitus and Weight Loss with Potential Application to Rare Obesity-related Genetic Disorders: A Commentary
Lucas Francis1, Merlin G. Butler2,*
- 1Kansas City University College of Osteopathic Medicine, Kansas City, MO 64106, USA
- 2Departments of Psychiatry & Behavioral Sciences and Pediatrics, University of Kansas Medical Center, Kansas City, KS 66160, USA
Corresponding Author
Merlin G. Butler, mbutler4@kumc.edu
Received Date: April 29, 2026
Accepted Date: June 15, 2026
Francis L, Butler MG. Glucagon-like Peptide-1 Receptor Agonists in Treating Diabetes Mellitus and Weight Loss with Potential Application to Rare Obesity-related Genetic Disorders: A Commentary. J Cell Signal. 2026;7(2):64–72.
Copyright: © 2026 Francis L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
Energy Expenditure and Nutrition in Neurogenic Obesity following Spinal Cord Injury
Worldwide, obesity is a public health concern and a metabolic ailment characterized by excessive adipose tissue accumulation resulting from an imbalance of energy expenditure and energy intake [1]. This disorder is a known risk factor for cardiovascular disease, type 2 diabetes mellitus, dyslipidemia, hypertension, and metabolic
Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1
Obesity has reached a global epidemic and it predisposes to the development of insulin resistance, type 2 diabetes and related metabolic diseases. Current interventions against obesity and/or type 2 diabetes such as calorie restriction, exercise, genetic manipulations or established pharmacological treatments have not been successful for many patients with obesity and/or type 2 diabetes.
Obesity, Family History of Diabetes, and Consanguineous Marriages are Risk Factors among Urban Population in South Indian City of Bengaluru
In 2017, approximately 424.9 million adults (age 20- 79 yrs) were affected by diabetes, with 4 million deaths. Global diabetes burden is estimated to increase up to 628.9 million people. Moreover, diabetes care costed approximately $727 billion in 2017.
Polycyclic Aromatic Hydrocarbons and Mammary Cancer Risk: Does Obesity Matter too?
Breast cancer is the most commonly diagnosed cancer in women in the United States. Breast cancer incidence rates, particularly among younger women, have been increasing since the 1930s, and are only partially explained by changes in parity, age at first birth, and improved screening and detection. Many questions remain unanswered regarding the mechanisms that underlie current risk.
Continuing Medical Education Rarely Addresses Leading Public Health Problems Including Diabetes and Obesity
Medical schools sponsor continuing medical education (CME) to help fulfill their mission of improving the health of the community. CME programs can help physicians stay up-to-date with the best practices associated with disease prevention and treatment.