Research Article Open Access
Volume 2 | Issue 2 | DOI: https://doi.org/10.33696/Nanotechnol.2.021

Folic acid-chitosan Nanomaterials for delivery of dietary polyphenols

  • 1Department of Chemistry-Biochemistry-Physics, Université du Québec à Trois-Rivières, C. P. 500, Trois-Rivières (Québec), Canada
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Corresponding Author

H. A. Tajmir-Riahi, heidar-ali.tajmir-riahi@uqtr.ca

Received Date: May 26, 2021

Accepted Date: July 01, 2021


The encapsulation of antioxidant resveratrol, genistein, and curcumin by folic acid-chitosan nanoparticles was studied in aqueous solution, using multiple spectroscopic methods, TEM images and modeling. Structural analysis showed that polyphenol bindings are via hydrophilic, hydrophobic, and H-bonding contacts with resveratrol forming more stable conjugates. As chitosan size increased, the binding efficacy and stability of polyphenol-polymer adducts were increased. Polyphenol binding induced major alterations of chitosan morphology. Folic acid-chitosan nanoparticles are capable of delivering polyphenols in vitro.


Polyphenols, Folic acid-chitosan, Encapsulation, Loading efficacy, TEM

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