Short Communication Open Access
Volume 1 | Issue 1 | DOI: https://doi.org/10.33696/Signaling.1.001
Flow Cytometric Characterization of Accidental Cell Death Highlights Connections to Regulated Cell Death
Gary Warnes1,*
- 1Flow Cytometry Core Facility, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, 4 Newark Street, London E1 2AT, UK
Corresponding Author
Gary Warnes, g.warnes@qmul.ac.uk
Received Date: December 10, 2019
Accepted Date: January 03, 2020
Warnes G. Flow Cytometric Characterization of Accidental Cell Death Highlights Connections to Regulated Cell Death. J Cell Signal 2020; 1(1): 1-3.
Copyright: © 2020 Warnes G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
Constitutively Active Death Receptor Induces Apoptosis in Mammalian Cells
Apoptosis is a physiological response in development and homeostasis of metazoans. Apoptosis is triggered during pathological events as a means to renew affected tissues and eliminate cancer cells. The immune system regulates the extrinsic pathway of apoptosis, where signals such as TNFα or displayed ligands on the surface of immune cells trigger signal cascades by death receptors present on targeted cells.
Impact of Cisplatin Dosing Regimens on Mammary Tumor Growth in an Animal Model
In a recent paper, we introduced a variant of the classical Simeoni tumor growth model, and illustrated its value in assessing tumor growth in a reproducible mouse model for mammary tumors. Our modification consisted of incorporating delay differential equations in the mathematical formulation of the Simeoni model, to represent the delay in drug action often observed under chemotherapeutic or immunotherapeutic regimens.
The Effect of Glucocorticoids on Angiogenesis in the Treatment of Solid Tumors
Glucocorticoids (GCs) are defined by their role in maintaining glucose homeostasis and natural GCs are a class of corticosteroids secreted by the adrenal cortex. Cortisol is the most important natural GC in humans. Cellular cortisol levels are regulated by the tissue-specific metabolic enzymes 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD 1 and 2); 11β-HSD 1 converts inactive cortisone to active cortisol, while 11β-HSD 2 has the opposite function.
Can Filtration Technology Advance Culture of Circulating Tumor Cells towards Precision Medicine?
Today, cancer is the second leading cause of death, with about 9.6 million deaths globally in 2018 [1]. At the end of the 19th century, Paul Ehrlich contributed a milestone to cancer research by introducing chemotherapy as a promising tumor treatment approach. Since then, cancer treatment has undergone tremendous advances, with chemotherapy still being a widely used cancer treatment method today, however, often associated with severe side effects.
Influence of Clinical Risk Factors on Outcomes in Men with Stage I Non-Seminomatous Germ Cell Tumor Undergoing Robot-Assisted Retroperitoneal Lymph Node Dissection
Retroperitoneal lymph nodes are often the first landing site of metastatic disease in men with testicular cancer. Primary retroperitoneal lymph node dissection (RPLND) for clinical stage I NSGCT can accurately surgically stage patients who may have nodal micrometastases, and in some cases, can serve as the primary therapy when volume of metastasis is low.