Review Article Open Access
Volume 2 | Issue 4 | DOI: https://doi.org/10.33696/Signaling.2.056

Ethanol Consumption and Sepsis: Mechanisms of Organ Damage

  • 1Departamento de Alimentos e Medicamentos, Universidade Federal de Alfenas (UNIFAL-MG), Minas Gerais, Brasil
  • 2Division of Pulmonary, Critical Care, Occupational and Sleep Medicine, Indiana University, Indianapolis, IN, USA
  • 3Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto (UFOP), Minas Gerais, Brasil
+ Affiliations - Affiliations

Corresponding Author

Carla Speroni Ceron, carla.ceron@ufop.edu.br

Received Date: June 30, 2021

Accepted Date: September 29, 2021


Sepsis is highly prevalent, and is one of the main causes of mortality among hospitalized patients. Ethanol consumption in large quantities compromises the normal functioning of the body, leading to dysfunction of multiple different organ systems. The association between sepsis and ethanol is not fully understood, but it is well accepted that ethanol consumption plays a role in the development of sepsis. Both sepsis and ethanol cause inflammatory dysfunction and promote oxidative stress. Antioxidant agents may be highly relevant targets to abrogate the effects of sepsis in patients who also consume large amounts of ethanol. This review focuses on presenting the main mechanisms involved between sepsis and ethanol consumption, and to describe the main antioxidants that have been used as therapeutic agents.


Ethanol consumption, Sepsis, Oxidative stress, Antioxidant defense, Inflammation, Antioxidant agents, Sepsis mortality

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