Readmission after ischemic stroke is common and poses immense social and financial burden on the patient, family, and healthcare system. It is therefore crucial for caregivers to recognize the most vulnerable patient population to provide targeted intervention. The study using recent State Inpatient Database demonstrated that patient socioeconomic status and discharge destination are associated with the risk of readmission. Patients living in the zip code area where household income are at the bottom quartile in the United States are at significantly higher risk for readmission. Compared to those being discharged to home, patients leaving against medical advice and discharged to a skilled nursing or rehabilitation facility are at higher risk of readmission.