Research Article Open Access
Volume 4 | Issue 2 | DOI: https://doi.org/10.33696/immunology.4.135

BIOMODULINA T® Modulates Lymphocyte Compartments in Institutionalized Cuban Geriatric Patients

  • 1Institute of Hematology and Immunology, Cuba
  • 2Head of the Clinical Trials Group of the Research and Development Directorate, National Center for Biopreparations (BioCen),Cuba
  • 3Higher Institute of Technologies and Applied Sciences, Cuba
  • 4Head of the National Group of Gerontology and Geriatrics, Sub Director of Medical Assistance CITED, Cuba
+ Affiliations - Affiliations

Corresponding Author

Imilla Casado Hernandez, icasado@infomed.sld.cu; icasadohernandez@gmail.com

Received Date: October 12, 2021

Accepted Date: February 28, 2022


BIOMODULINA T® is a biological immunomodulator of natural origin, not blood derived, which promises to be a strategy for immune restoration in the elderly, in the midst of the worldwide epidemiological crisis due to the SARS-CoV-2 virus. This research aimed to determine the changes induced by BT in the distribution of lymphocyte compartments of institutionalized Cuban geriatric patients. The significant expansion of the naïve CD4+ and CD8+, CD19+, NK T cells and of the CD3+ HLA-DR+ and CD3+ CD25+ activation populations was observed; while the rest of the populations of T, B compartments, the T population that co-express CD4 and CD8, and the CD4-CD8-TCRαβ + T cells did not show significant changes. BT had an effect on the immune restoration of T and B lymphocyte populations of Cuban older adults. It modulates the immune response and inflammation, restores immunity, and can contribute to a strategy to prevent and treat COVID-19 in elderly.


B lymphocytes, T lymphocytes, Naïve T cells, Lymphocyte activation, Elderly, Immunosnescence, BIOMODULINA T®

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