BIOMODULINA T^® is a biological immunomodulator of natural origin, not blood derived, which promises to be a strategy for immune restoration in the elderly, in the midst of the worldwide epidemiological crisis due to the SARS-CoV-2 virus. This research aimed to determine the changes induced by BT in the distribution of lymphocyte compartments of institutionalized Cuban geriatric patients. The significant expansion of the naïve CD4⁺ and CD8⁺, CD19⁺, NK T cells and of the CD3⁺ HLA-DR⁺ and CD3⁺ CD25⁺ activation populations was observed; while the rest of the populations of T, B compartments, the T population that co-express CD4 and CD8, and the CD4-CD8-TCRαβ + T cells did not show significant changes. BT had an effect on the immune restoration of T and B lymphocyte populations of Cuban older adults. It modulates the immune response and inflammation, restores immunity, and can contribute to a strategy to prevent and treat COVID-19 in elderly.

B lymphocytes, T lymphocytes, Naïve T cells, Lymphocyte activation, Elderly, Immunosnescence, BIOMODULINA T^®