Volume 1 | Issue 4 | DOI: https://doi.org/10.33696/haematology.1.020
Anticancer and Antiviral Activity of the Pyridine-Biphenyl Glycoside System
Ahmed I. Khodair1,*, Adel M. Attia1, Eman A. Gendy1, Yaseen A. M. M. Elshaier2, Mohammed A. El-Magd3
- 1Chemistry Department, Faculty of Science, kafrelshiekh University, El-Geish Street, kafrelshiekh, Post Box 33516, Egypt
- 2Department of Organic and Medicinal chemistry, Faculty of Pharmacy, University of Sadat City, Menoufiya, 32897, Egypt
- 3Anatomy Department, Faculty of Veterinary Medicine, Kafrelshiekh University, El-Geish Street, kafrelshiekh, Post Box 33516, Egypt
Ahmed I. Khodair, email@example.com
Received Date: November 11, 2020
Accepted Date: December 29, 2020
Khodair AI, Attia AM, Gendy EA, Elshaier YAMM, El-Magd MA. Anticancer and Antiviral Activity of the Pyridine- Biphenyl Glycoside System. J Clin Haematol. 2020; 1(4):132-143.
Copyright: © 2020 Khodair AI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Breast cancer is the most frequent malignancy in females. Due to its major impact on the population, this disease represents a critical public health problem that requires further research at the molecular level to define its prognosis and specific treatment. Basic research is required to accomplish this task and this involves cell lines as they can be widely used in many aspects of laboratory research and, particularly, as in vitro models in cancer research. MCF-7 is a commonly used breast cancer cell line, that has been promoted for more than 40 years by multiple research groups but its characteristics have never been gathered in a consistent review article.
According to the report published recently by the World Health Organization, the number of cancer cases in the world will increase to 22 million by 2030. So, the anticancer drug research and development is taking place in the direction where the new entities are developed which are low in toxicity and are with improved activity. Pyridine and their pyridine-biphenyl system derivatives represent a very important class of heterocyclic compounds, which have a diverse therapeutic area. Recently, many active compounds synthesized are very effective; natural products isolated with pyridine moiety have also shown to be potent towards cancer.