Case Report Open Access
Volume 2 | Issue 4 | DOI: https://doi.org/10.33696/haematology.2.037

Acute Myeloid Leukaemia with inv (16) in a 2-year-old Boy: A Diagnostic Dilemma

  • 1Department of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children, Kabul, Afghanistan
  • 2Department of Paediatric medicine, French Medical Institute for Mothers and Children, Kabul, Afghanistan
  • 3Department of Haemato-Oncology, Jumhoriat Hosptial, Kabul, Afghanistan
  • 4Department of Haemato-Oncology, Amiri Medical Complex, Kabul, Afghanistan
+ Affiliations - Affiliations

Corresponding Author

Ahmed Maseh Haidary, ahmedmaseh.haidary@fmic.org.af

Received Date: August 25, 2021

Accepted Date: September 08, 2021


Background: In the past three decades, there has been significant improvements in the diagnosis and management of acute myeloid leukaemia. Cytogenetic and molecular genetic modalities have now enabled physicians to identify and plan appropriate management protocols for patients according to genetic profile.

Case presentation: Here we present case of a 2-year-old boy who initially presented with features that were clinically and haematologically suggestive of juvenile myelomonocytic leukaemia (JMML), but cytogenetic analysis revealed presence of inv(16)/t(16;16) (p13q22) (CBFB/MYH11), which is the recurrent cytogenetic abnormality associated with AML.

Conclusion: To our knowledge this was the first case of acute myeloid leukaemia with inv(16)/t(16;16) (p13q22) diagnosed in a two year old baby. In our patient, cytogenetic analysis helped with correct diagnosis. Cytogenetic and molecular genetic studies now play an important role in diagnosis, as well as management of clonal disorders, including acute leukaemias.


AML, inv(16), 2-Year-Old, Diagnostic, Dilemma

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