Archives of Nephrology and Renal Studies

Commentary Open Access

NSAID-associated Renal Injury: Mechanisms, Risks, and Safer Strategies

Muhammad Umar Ahsan , Umme Ambreen , Hassan Javed , Nirmal Noor , Mahnoor Jan , Muhammad Naeem Khan

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesics that have a high risk of renal injury, especially in susceptible populations such as the elderly, patients with chronic kidney disease (CKD), heart failure, or those on poly pharmacy. This commentary emphasizes the pathophysiological mechanisms of NSAID-induced kidney damage, including prostaglandin inhibition, renal vasoconstriction, and interstitial nephritis—and highlights recent evidence linking NSAIDs to acute kidney injury (AKI) and CKD progression.

Arch Nephrol Ren Stud, 2025, Volume 5, Issue 1, p1-5 | DOI: 10.33696/nephrology.5.013

Original Research Open Access

Factors Associated with Psychiatric Vulnerability in Patients with End-Stage Renal Disease at the Zou/Collines Departmental Hospital, Benin

Séraphin Ahoui , Joseph Godonou , Aimé Vinassé , Aubin Melikan , Jaurel Godjo , Elfreed Alavo , Jacques Akobi , Eric Lossou , Sécondine Gnitoungbe , Sylvain Glitho , Francis Tognon Tchegnonsi

Introduction: End-stage chronic kidney disease (CKD) poses a significant challenge to patients' mental health, frequently leading to anxiety, depression, and sleep disturbances. This study aimed to identify factors associated with psychiatric vulnerability among patients with end-stage renal disease at the Zou/Collines Departmental Hospital in Benin. Methods: We conducted a cross-sectional study from January to June 2024, including patients with end-stage renal disease managed in the internal medicine department.

Arch Nephrol Ren Stud, 2025, Volume 5, Issue 1, p6-13 | DOI: 10.33696/nephrology.5.014