Archives of Gastroenterology Research

Mini Review Open Access

Gastrointestinal Reflux Related Aspiration (GRASP) and Airway Injury after Lung Transplantation: Insights into Pathophysiology and Role of Airway Biomarkers for Risk Stratification

Miguel M. Leiva-Juarez, MD, MSE , Frank D’Ovidio, MD, PhD

Lung transplantation remains the only long term treatment for end-stage pulmonary disease. The main limitation to allograft survival beyond the first year post transplant is development of chronic lung allograft dysfunction (CLAD). Among survivors, CLAD will develop in virtually all recipients and often will show signs of airway injury before any clinical manifestations appear. There is currently no specific treatment available and management depends largely on modification of risk factors. Recent efforts by our group and others have focused on understanding the underlying pathophysiology and development of clinical biomarkers to diagnose CLAD early and allow risk stratification before irreversible allograft injury.

Arch Gastroenterol Res, 2025, Volume 6, Issue 1, p1-7 | DOI: 10.33696/Gastroenterology.6.058

Case Report Open Access

Disease Resolution after Cessation of Treatment in Patients with Eosinophilic Esophagitis

Qian Yuan , Jonathan N. Glickman , Wayne G. Shreffler

Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus. EoE is triggered in most patients by dietary allergens and mediated by type 2 immune responses. Over the past 3 decades, substantial progresses have been made in understanding EoE pathogenesis, management, and natural history. EoE affects children and adults, and the incidence and prevalence have increased over time. Untreated EoE can lead to severe complications including food impaction, small caliber esophagus, esophageal stricture, and esophageal perforation.

Arch Gastroenterol Res, 2025, Volume 6, Issue 1, p8-12 | DOI: 10.33696/Gastroenterology.6.059

Mini Review Open Access

Food Protein-Induced Allergic Proctocolitis (FPIAP): New Insights into Pathogenesis and Implications

Qian Yuan

Food protein induced allergic proctocolitis (FPIAP) is one of the earliest presentations of food allergies in infancy. It is a non-immunoglobulin E (IgE)-mediated condition. Although the inflammation is located at the rectosigmoid colon, clinical symptoms are not limited to mucousy, bloody stools and often include gastroesophageal reflux (GER), feeding difficulties, irritability and poor sleep. 

Arch Gastroenterol Res, 2025, Volume 6, Issue 1, p13-18 | DOI: 10.33696/Gastroenterology.6.060