Archives of Cancer Biology and Therapy

Commentary Open Access

Exploring Cell Differentiation, Induced by Inhibition of Phospholipase C/Protein Kinase C Cascade, as a Potential Therapeutic Strategy against Rhabdomyosarcoma

Nicolás Blanco , Natalia Frattini , Lucía Pronsato , Lorena Milanesi , Andrea Vasconsuelo

Among the reasons of childhood mortality, cancer is the leading cause of death. Of all paediatric cancers diagnosed, soft tissue sarcomas account for 7%, of which approximately 50% are rhabdomyosarcoma (RMS), with an incidence of 4.71 per million children and adolescents. Rhabdomyosarcoma (RMS) is the most common soft-tissue tumour in children and adolescents. This aggressive childhood cancer originates in normal skeletal muscle from myogenic cells that have failed to fully differentiate. 

Arch Cancer Biol Ther, 2025, Volume 3, Issue 1, p1-4 | DOI: 10.33696/cancerbiology.3.027

Case Report Open Access

Pseudoaneurysm of the Breast after Diagnostic Core-Needle Biopsy: Contextualizing Impact on Treatment

Caroline Lommer , Brandy M. Griffith , Ashley P Davenport , Gary Tozbikian , Doreen M. Agnese , Sara P. Myers

This case report considers an iatrogenic pseudoaneurysm (PSA), a rare event occurring in fewer than 2% of patients, after a core-needle biopsy of the breast in a 46-year-old with stage IIIC triple negative invasive breast carcinoma on preoperative chemoimmunotherapy with the PD-1 inhibitor pembrolizumab. A post-biopsy MRI (magnetic resonance imaging) demonstrated a well-defined, contrast-enhancing lesion with pulsatile flow consistent with PSA.

Arch Cancer Biol Ther, 2025, Volume 3, Issue 1, p5-9 | DOI: 10.33696/cancerbiology.3.028

Commentary Open Access

From Tiny Fish to Big Impact: Automating Zebrafish Microinjections for Cancer Research and Beyond

Yi Ding , Lasse D. Jensen , Jan de Sonneville

Zebrafish xenograft models have become indispensable in cancer biology for their capacity to recapitulate key aspects of human tumor progression in a live vertebrate system. However, widespread adoption has been constrained by the technical demands of microinjection, which require extensive training, result in operator variability, and limit scalability. 

Arch Cancer Biol Ther, 2025, Volume 3, Issue 1, p10-13 | DOI: 10.33696/cancerbiology.3.029