Archives of Cancer Biology and Therapy

Commentary Open Access

Tunable Acoustofluidic Permeabilization for Mechano-Chemotherapy— A Commentary

Jianing Liu , Ke Li , Ruoyu Zhong

Conventional chemotherapy is limited by systemic toxicity, poor tumor penetration, and drug resistance. While mechano-chemo therapy combining mechanical stimulation with chemicals shows promise, existing techniques are in the early stages. A bubble-free acoustofluidic platform using high-frequency surface acoustic waves to apply localized mechanical forces, named ChemoTAP, was developed.

Arch Cancer Biol Ther, 2026, Volume 4, Issue 1, p1-5 | DOI: 10.33696/cancerbiology.4.030