Archives of Molecular Biology and Genetics

Research Article Open Access

Karyotypic Profile of Chronic Myeloid Leukemia in Patients Diagnosed at Tertiary Level in Afghanistan

Abdul Hadi Saqib, Samuel Sharif, Ahmad Walid Yousufzai, Najla Nasir, Sarah Noor, Sahar Noor, Abdul Jamil Rasooli, Ahmad Shekib Zahier, Ramin Saadaat, Haider Ali Malakzai, Abdul Sami Ibrahimkhil, Maryam Ahmad, Zeeshan Ansar Ahmed

Balanced translocation resulting in fusion of the Abelson gene (ABL₁) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2 is the pathognomonic molecular driver of CML. The resulting BCRABL 1 fusion gene is both the diagnostic as well as therapeutic target of CML. The first agent with tyrosine kinase inhibitor activity that was licenced in 2000 for treatment of CML patients, was Imatinib, gradually followed by multiple agents with higher efficacy.

Commentary Open Access

Escherichia coli Stress, Multi-cellularity, and the Generation of the Quorum Sensing Peptide EDF

Isabella Moll, Hanna Engelberg-Kulka

Bacterial communication via quorum sensing (QS) molecules, as well as toxin-antitoxin (TA) gene modules located on bacterial chromosomes are well-studied mechanisms. Escherichia coli mazEF is a stress-induced TA system mediating cell death requiring a QS extracellular death factor (EDF), the pentapeptide NNWNN. MazF is an endoribonuclease specific for ACA sites. During adverse conditions, the activated MazF generates a stress induced translation machinery, composed of MazF-processed mRNAs and selective ribosomes that specifically translate these processed mRNAs.

Review Article Open Access

The Nature of Radiation-induced Inherited Recessive Gene Mutations in Drosophila Melanogaster

ID Alexandrov, MV Alexandrova, KP Afanasyeva

The nature of gene mutations induced by ionizing radiation in germ cells and transmitted to offspring remains one of the most important problems in radiation genetics of higher eukaryotes. The data accumulated in this field were obtained by different authors under different experimental conditions which does not give a complete insight about the nature of radiation-induced inherited mutations at different genome levels (chromosome, gene, DNA). 

Short Communication Open Access

Constitutively Active Death Receptor Induces Apoptosis in Mammalian Cells

Peterson K, Palmer B, Christensen C, Bailey S, Mizrachi D

Apoptosis is a physiological response in development and homeostasis of metazoans. Apoptosis is triggered during pathological events as a means to renew affected tissues and eliminate cancer cells. The immune system regulates the extrinsic pathway of apoptosis, where signals such as TNFα or displayed ligands on the surface of immune cells trigger signal cascades by death receptors present on targeted cells.

Commentary Open Access

Commentary on NOBOX Mutations in Premature Ovarian Insufficiency

Asma Sassi, Julie Désir, Alexander Gheldof, Sonia Van Dooren, Xavier Peyrassol, Marc Abramowicz, Anne Delbaere

NOBOX is an ovarian specific transcription factor that plays an important role in follicular growth and survival. Nineteen NOBOX variants have been previously associated with premature ovarian insufficiency (POI). Disease severity in patients with heterozygous and homozygous mutations largely overlap however, hampering genotype-phenotype correlations. We recently reported the first case of biallelic truncating mutations (NM_001080413.3 (NOBOX):c.826C>T, p.(Arg276*) and NM_001080413.3(NOBOX):c.1421del, p.(Gly474Alafs*76)) of NOBOX in two Belgian sisters with POI.