Renalase, a newly discovered flavin-adenine dinucleotide-dependent amine oxidase released by the kidney, circulates in the blood and has an impact on heart function and systemic blood pressure. We conducted the research in Babylon from February to July of 2016. We collected 50 blood samples from patients with end stage renal disease admitted to Merjan Teaching Hospital in Babylon Province, Iraq. In addition to the control group (50 samples) of healthy people aged 11 to 80, all patients and control groups were from the same ethnic group (Arab). The current study's findings revealed the mean variation of renalase level (pg/ml) across patient and control groups. Renalase levels were much higher (P <0.05) in the serum of people with end-stage renal disease (184.21± 4.97 pg/ml) than in the healthy group (44.06 ±7.21 pg/ml). The findings showed that people with end-stage renal failure were more likely to have GG, GA, and AA in the renalase (RNLS) gene (18%, 20%, and 62%) than people in the control group (19.3%, 22%, and 58.7%). In the Iraqi population, the Renalase (rs2576178) G>A mutation was not related with vulnerability to end-stage renal failure.

Renalase, rs2576178, Polymorphisms, End stage renal disease, Kidney