Review Article Open Access
Volume 1 | Issue 4 | DOI: https://doi.org/10.33696/Signaling.1.028

The Role of TIGAR-mediated Metabolic Processes in Autophagy and Cell Survival

  • 1Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China
  • 2Department of Pediatrics Research Institute, Children’s Hospital of Soochow University, Suzhou, 215025, China
  • 3Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
+ Affiliations - Affiliations

Corresponding Author

Zheng-Hong Qin, qinzhenhong@suda.edu.cn

Received Date: September 11, 2020

Accepted Date: October 30, 2020


Autophagy is the one of the essential pathways for maintaining homeostasis of cells and plays an important regulatory role in cell survival and death. Tp53-induced glycolysis and apoptosis regulator (TIGAR) is a Tp53 target protein and is not only involved in the regulation of metabolism, cell cycle progression and radiation response, but also plays a role in autophagy. TIGAR regulates autophagy either to promote cell survival or contribute to cell death under diverse cellular environments. More research is required to define the differential roles of TIGAR in autophagy and cell survival under various pathophysiological conditions. In this review, we briefly discussed the influences of TIGAR on cell survival through regulating autophagy in different cell types to deepen the understanding of the relationship between TIGAR-mediated metabolic processes in autophagy and cell survival.


TIGAR, Autophagy, Cell survival, Apoptosis, Metabolism

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