Autophagy is the one of the essential pathways for maintaining homeostasis of cells and plays an important regulatory role in cell survival and death. Tp53-induced glycolysis and apoptosis regulator (TIGAR) is a Tp53 target protein and is not only involved in the regulation of metabolism, cell cycle progression and radiation response, but also plays a role in autophagy. TIGAR regulates autophagy either to promote cell survival or contribute to cell death under diverse cellular environments. More research is required to define the differential roles of TIGAR in autophagy and cell survival under various pathophysiological conditions. In this review, we briefly discussed the influences of TIGAR on cell survival through regulating autophagy in different cell types to deepen the understanding of the relationship between TIGAR-mediated metabolic processes in autophagy and cell survival.
TIGAR, Autophagy, Cell survival, Apoptosis, Metabolism