Review Article Open Access
Volume 4 | Issue 3 | DOI: https://doi.org/10.33696/Signaling.4.100

The Human Gut Phageome: Identification and Roles in the Diseases

  • 1Department of Biochemistry, Faculty of Biological Sciences, University of Tarbiat Modares, Tehran, Iran
  • 2Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • 3Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • 4Department of Radiology, Afzalipour Hospital, Kerman University of Medical Science, Kerman, Iran
  • 5Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • #These authors contributed equally as the first authors
+ Affiliations - Affiliations

Corresponding Author

Mohsen Nabi-Afjadi, mohsennabi66@gmail.com

Received Date: July 10, 2023

Accepted Date: August 04, 2023


The human gut is a complex environment that contains a diversity of microorganisms commonly known as the microbiome. Numerous factors influence the composition of human gut bacterial communities, either contributing to homeostasis or the instability associated with a variety of diseases. In this study, we discuss our understanding that proposes among the most influential factors are likely to be bacteriophages, bacteria-infecting viruses that make up a large percentage of the human gut microbiome, demonstrated to have an association with human health and diseases such as inflammatory bowel disease (IBD), cardiovascular disease (CVD), etc. to provide new therapeutic approaches.


Phageome, Bacteriophages, Microbiome, Gut health, Cardiovascular disease, Diabetes, Inflammatory bowel disease

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